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Merck

T9283

Sigma-Aldrich

Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal

clone CH1, purified from hybridoma cell culture

동의어(들):

Monoclonal Anti-Tropomyosin (Sarcomeric) antibody produced in mouse, Anti-C15orf13, Anti-CMD1Y, Anti-CMH3, Anti-HEL-S-265, Anti-HTM-alpha, Anti-LVNC9, Anti-TMSA

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

MDL number:
MFCD00149029
UNSPSC 코드:
12352203
NACRES:
NA.41

주요 문서

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기술 서비스
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기술 서비스
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도움 문의

생물학적 소스

mouse

Quality Level

200

결합

unconjugated

항체 형태

purified from hybridoma cell culture

항체 생산 유형

primary antibodies

클론

CH1, monoclonal

포함

15 mM sodium azide

종 반응성

human, chicken, rat

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using sections of human tongue
immunohistochemistry (frozen sections): suitable using human and animal tissue sections
immunoprecipitation (IP): suitable
microarray: suitable
western blot: suitable using native preparations

동형

IgG1

UniProt 수납 번호

P09493

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

chicken ... TPM1(396366)
human ... TPM1(7168)
rat ... Tpm1(24851)

일반 설명

Tropomyosin 1 (TPM1) is encoded by the gene mapped to human chromosome 15q22.2. The encoded protein belongs to the TPM protein family.

면역원

chicken muscle tropomyosin.

애플리케이션

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Monoclonal Anti-Tropomyosin (sarcomeric) antibody produced in mouse has been used in immunofluorescence and immunohistochemistry.

생화학적/생리학적 작용

The antibody recognizes an epitope on skeletal and cardiac tropomyosin. The antibody shows no reaction with denatured protein by immunoblotting. No cross-reactivity has been observed with smooth muscle or non-muscle tropomyosin.
Tropomyosin 1 (TPM1) is a potent tumor suppressor gene. It is expressed at low levels in various types of solid cancers including, oral squamous cell carcinoma (OSCC) and tongue squamous cell carcinoma. Mutation in the gene is associated with the development of hypertrophic cardiomyopathy. The encoded protein is involved in the regulation of actin-myosin interaction in striated muscles. Tropomyosin plays an essential role in Ca2+ -regulated contraction of cardiac muscle.

물리적 형태

Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
058M4770V
22180217
017M4852V
084M4849V
093M4791

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

K H Grinnemo et al.
The Journal of thoracic and cardiovascular surgery, 127(5), 1293-1300 (2004-04-30)
It is thought that adult human mesenchymal stem cells do not induce immunoreactivity even to xenografts. We wanted to study whether adult human mesenchymal stem cells survive and engraft in experimentally induced ischemic rat myocardium. Bone marrow-derived adult human mesenchymal
Natalie Gude et al.
Circulation research, 99(4), 381-388 (2006-07-15)
Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been explored in the context of the myocardium. Cardiac-specific expression of nuclear-targeted Akt (Akt/nuc) in transgenics prolongs
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
Pan H
PLoS ONE, 12, e0168900-e0168900 (2017)
Myofibril Degeneration Caused by Tropomodulin Overexpression Leads to Dilated Cardiomyopathy in Juvenile Mice
Sussman MA
The Journal of Clinical Investigation, 101, 51-61 (1998)
Martinus I F J Oerlemans et al.
Basic research in cardiology, 105(5), 631-641 (2010-04-08)
Although the contribution of Wnt signaling in infarct healing is suggested, its exact role after myocardial infarction (MI) still needs to be unraveled. We evaluated the cardiac presence of active Wnt signaling in vivo following MI, and investigated in which
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