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Merck

SML0837

Sigma-Aldrich

FAK Inhibitor 14

≥95% (HPLC)

동의어(들):

1,2,4,5-Benzene tetraamine tetrahydrochloride, 1,2,4,5-Benzenetetraamine 4HCl, 1,2,4,5-Benzenetetraamine tetrahydrochloride, Benzene-1,2,4,5-tetramine tetrahydrochloride, NSC 667249, Y15

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C6H10N4 · 4HCl
CAS 번호:
4506-66-5
Molecular Weight:
284.01
EC Number:
224-822-6
UNSPSC 코드:
12352200
NACRES:
NA.77

주요 문서

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Quality Level

100

분석

≥95% (HPLC)

양식

powder

저장 조건

desiccated

색상

, faint purple to dark brown

solubility

H2O: 20 mg/mL, clear

저장 온도

room temp

SMILES string

[Cl-].[Cl-].[Cl-].[Cl-].Nc1c(cc(c(c1)N)N)N.[H+].[H+].[H+].[H+]

InChI

1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H

InChI key

BZDGCIJWPWHAOF-UHFFFAOYSA-N

관련 카테고리

애플리케이션

FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.

생화학적/생리학적 작용

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor.
1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
085M4705V
103M4738V

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문서

Focal Adhesion Kinase (FAK) Overview

The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase. FAK has been implicated as a downstream signaling molecule that functions in the control of several integrin-regulated biological processes.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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