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Merck

SBR00123

Colistin Sulfate

Ready Made Solution, 10 mg/mL (in H2O)

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC 코드:
51101500

주요 문서

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Quality Level

200

양식

ready-to-use solution

농도

10 mg/mL (in H2O)

색상

colorless to yellow

항생제 활성 스펙트럼

Gram-negative bacteria

동작 모드

cell membrane | interferes

배송 상태

dry ice

저장 온도

2-8°C

SMILES string

CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O

InChI

1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1

InChI key

ZJIWRHLZXQPFAD-LRYSGCCDSA-N

일반 설명

Colistin (Polymyxin E) is a polycationic peptide antimicrobial agent that inhibits gram negative bacteria.

애플리케이션

  • Colistin has been used for multi drug resistant infections bacilli like: Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii.[9-13]
  • To permeabilize to bacteria cell membrane to learn mannose-resistant haemagglutination and antibiotic resistance in A. baumannii  strain.[14]
  • For nephrotoxicity study in rat kidney.[15] and for MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa.[16]
  • To induce cell toxicity in 24h on PC-12 cell line, causing decrease of cell viability ~by 75% with concentration of 125µg/ml colistin sulfate.[17]
  • To show cell toxicity affect in dose (3-100µg/ml) dependent manner against HK-2 cells as part of a study to learn on the mechanism of colistin inducing nephrotoxicity.[18]

생화학적/생리학적 작용

Mode of Action: Colistin mode of action is by forming electrostatic interaction with lipid A phosphate groups of lipopolysaccharide (LPS) of gram negative bacilli1 and disrupting physical integrity of the cell wall.2 Colistin shows indirect anti-endotoxin activity by binding to lipid A as it targets the endotoxin and neutralize the LPS component of the bacteria.[3-5]

Antimicrobial Spectrum: Colistin has microbial activity against Enterobacteriaceae family members like E. coli, Enterobacter spp., Klebsiella spp., Citrobacter spp., Salmonella spp., and Shigella spp. Colistin is also active against nonfermentive gram-negative bacteria, like Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia [6-8] and also against other gram negative species.[9]

특징 및 장점

High quality antibiotic suitable for mulitple research applications

제조 메모

Colistin Ready Made Solution is provided as a solution of 10mg/ml in water and aseptically dispensed.Colistin concentration range for the uses or applications mentioned above is 0.25-125µg/ml.Colistin Ready Made Solution should be diluted respectively by 80-40,000.

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