SAB1304574
ANTI-TET2 (N-TERM) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
동의어(들):
KIAA1546, Probable methylcytosine dioxygenase TET2, TET2
생물학적 소스
rabbit
결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
223811 Da
종 반응성
human
기술
western blot: 1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TET2(54790)
일반 설명
Tet methyl cytosine dioxygenase 2 (TET2), a TET oncogene family member 2/ten-eleven translocation 2, is a tumour suppressor gene which encodes a DNA demethylase enzyme. In human chromosome, the gene TET2 is localized on 4q24.
생화학적/생리학적 작용
Tet methyl cytosine dioxygenase 2 (TET2) catalyses the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. TET2 is essential for normal myelopoiesis, epigenetic programming, embryonic stem cell maintenance and early development. Mutations in TET2 leads to myelodysplastic syndromes (MDS), myeloproliferative disorder, myeloproliferative neoplasms (MPN). Mutations also causes different leukaemia like chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML), secondary AML (sAML) and myeloid malignancies. TET2 regulates mast cell differentiation and proliferation and cytokine production.
물리적 형태
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Ko M, et al.
Nature, 468(7325), 839-839 (2010)
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
Figueroa ME, et al.
Cancer Cell, 18(6), 553-567 (2010)
Mutation in TET2 in myeloid cancers
Delhommeau F, et al.
The New England Journal of Medicine, 360(22), 2289-2301 (2009)
TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities
Montagner S, et al.
Cell Reports, 15(7), 1566-1579 (2016)
The role of TET2 in hematologic neoplasms
Holmfeldt L and Mullighan CG
Cancer Cell, 20(1), 1-2 (2011)
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