P9255
Pyridoxal 5′-phosphate hydrate
≥98%
동의어(들):
Pyridoxal phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C8H10NO6P · xH2O
CAS 번호:
Molecular Weight:
247.14 (anhydrous basis)
Beilstein:
234749
EC Number:
MDL number:
UNSPSC 코드:
12352205
PubChem Substance ID:
NACRES:
NA.79
생물학적 소스
synthetic (organic)
Quality Level
분석
≥98%
양식
powder
기술
HPLC: suitable
색상
beige
off-white to yellow
mp
140-143 °C
저장 온도
−20°C
SMILES string
CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
InChI
1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChI key
NGVDGCNFYWLIFO-UHFFFAOYSA-N
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일반 설명
Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.
애플리케이션
Pyridoxal 5′-phosphate hydrate has also been used:
- as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)
- in D-amino acid transaminase reaction(10)
- as a cofactor for L-glutamic acid decarboxylase
생화학적/생리학적 작용
Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS) cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and D-serine dehydratase.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin
Calderon-Ospina CA, et al.
CNS Neuroscience & Therapeutics (2019)
Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5?-phosphate biosynthesis
Belitsky BR
Journal of Bacteriology, 186(4), 1191-1196 (2004)
Structure of the cystathionine gamma-synthase MetB from Mycobacterium ulcerans
Clifton MC, et al.
Acta Crystallographica. Section F, Structural Biology Communications, 67(9), 1154-1158 (2011)
Preparation, Stimulation and Other Uses of Adult Rat Brain Synaptosomes
Modi J, et al.
Bio-protocol, 7(24) (2017)
Structure of the mitochondrial aminolevulinic acid synthase, a key heme biosynthetic enzyme
Brown BL, et al.
Structure, 26(4), 580-589 (2018)
문서
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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