P7412
Pirenzepine dihydrochloride
≥98% (TLC), muscarinic acetylcholine receptor antagonist, powder
동의어(들):
5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H21N5O2 · 2HCl
CAS 번호:
Molecular Weight:
424.32
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
제품 이름
Pirenzepine dihydrochloride, ≥98% (TLC), powder
Quality Level
분석
≥98% (TLC)
양식
powder
색상
white to light yellow
solubility
H2O: 50 mg/mL
SMILES string
Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
InChI
1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
InChI key
FFNMBRCFFADNAO-UHFFFAOYSA-N
유전자 정보
human ... CHRM1(1128)
관련 카테고리
일반 설명
Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.
애플리케이션
Pirenzepine dihydrochloride has been used
- in transactivation of fibroblast growth factor receptor (FGFR).
- as a supplement in cell culture.
- for the stimulation of human fibroblasts
생화학적/생리학적 작용
Selective M1 muscarinic acetylcholine receptor antagonist.
특징 및 장점
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
면책조항
Hygroscopic; store desiccated at room temperature.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
V B Aramakis et al.
Synapse (New York, N.Y.), 32(4), 262-275 (1999-05-20)
Previously, we reported that activation of muscarinic receptors modulates N-methyl-D-aspartate (NMDA) receptor-mediated synaptic transmission in auditory neocortex [Aramakis et al. (1997a) Exp Brain Res 113:484-496]. Here, we describe the muscarinic subtypes responsible for these modulatory effects, and a role for
Pirenzepine Dihydrochloride
El-Obeild HA, et al.
Anal. Profiles Drug Subst., 16, 445-506 (1987)
Pirenzepine
Carmine AA and Brogden RN
Drugs, 30(2), 85-126 (1985)
Muscarinic acetylcholine type 1 receptor activity constrains neurite outgrowth by inhibiting microtubule polymerization and mitochondrial trafficking in adult sensory neurons
Sabbir MG, et al.
Frontiers in Neuroscience, 12(3), 229-237 (2018)
A Elhusseiny et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 19(7), 794-802 (1999-07-21)
Acetylcholine is an important regulator of local cerebral blood flow. There is, however, limited information available on the possible sites of action of this neurotransmitter on brain intraparenchymal microvessels. In this study, a combination of molecular and functional approaches was
문서
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DISCOVER Bioactive Small Molecules for Neuroscience
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