P6503

Pilocarpine hydrochloride

Name: Pilocarpine hydrochloride
Brand: SIGMA

≥99% (titration), powder, muscarinic acetylcholine receptor agonist

동의어(들):

(3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₁H₁₆N₂O₂ · HCl

CAS 번호:

54-71-7

Molecular Weight:

244.72

Beilstein:

4034491

EC Number:

200-212-5

MDL number:

MFCD00012722

UNSPSC 코드:

12352200

PubChem Substance ID:

24277862

NACRES:

NA.77

주요 문서

모든 문서 보기

기술 서비스

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제품 이름

Pilocarpine hydrochloride, ≥99% (titration), powder

Quality Level

100

분석

≥99% (titration)

양식

powder

기술

HPLC: suitable
gas chromatography (GC): suitable

색상

white

mp

202-205 °C (lit.)

solubility

H₂O: 100 mg/mL

응용 분야

forensics and toxicology
veterinary

SMILES string

Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1

InChI key

RNAICSBVACLLGM-GNAZCLTHSA-N

유전자 정보

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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애플리케이션

Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice. It has also been used to induce status epilepticus(SE) in rat.

생화학적/생리학적 작용

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pilocarpine is alkaloid isolated from the shrub Pilocarpus species. It comprises imidazole ring and γ- lactone rings in its structure. It has cholinergic potential and it stimulates the parasympathetic system. Pilocarpine is also effective for treating glaucoma. It stimulates ciliary muscle contraction by binding to muscarinic M3 receptors. It is effective in treating corneal dryness in Sjogren′s syndrome. It is a secretagogue, which improves salivary secretions in Xerostomia or a dry mouth condition in Sjogren′s syndrome patients and in radiotherapy patients with head and neck carcinoma.

특징 및 장점

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.