O9512

Oxaliplatin

Name: Oxaliplatin
Brand: SIGMA

Apoptosis inducer, powder

동의어(들):

[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum

로그인조직 및 계약 가격 보기

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₈H₁₄N₂O₄Pt

CAS 번호:

61825-94-3

Molecular Weight:

397.29

MDL number:

MFCD00866327

UNSPSC 코드:

12352200

PubChem Substance ID:

329818942

NACRES:

NA.77

주요 문서

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제품 이름

Oxaliplatin, powder

양식

powder

Quality Level

100

주관자

Sanofi Aventis

저장 온도

2-8°C

SMILES string

O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

InChI key

ZROHGHOFXNOHSO-BNTLRKBRSA-L

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애플리케이션

Oxaliplatin has been used:

as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay
for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay
to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells

생화학적/생리학적 작용

Oxaliplatin a platinum analogue, causes DNA damage and cell death by binding to DNA and forming inter and intrastrand crosslinks preventing replication and transcription. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin is an approved drug for treating colorectal cancer. It is an active ingredient in FOLFOX (Folinic acid:5-FU:oxaliplatin in the ratio 1:10:1 of micromolar concentrations respectively). Oxaliplatin causes both acute and chronic neurotoxicity in patients in a dose dependent manner and is reversible either by reducing or stopping the drug.

특징 및 장점

This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox and Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

GHS08,GHS05

신호어

Danger

유해 및 위험 성명서

H317,H318,H334,H341,H351,H360FD,H362,H372

예방조치 성명서

P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

SUMOylation alterations are associated with multidrug resistance in hepatocellular carcinoma

Qin Y, et al.

Molecular Medicine Reports, 9(3), 877-881 (2014)

Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study

Votanopoulos KI, et al.

Annals of Surgical Oncology, 1-9 (2018)

Expression of an oncogenic BARD1 splice variant impairs homologous recombination and predicts response to PARP-1 inhibitor therapy in colon cancer

Ozden O, et al.

Scientific Reports, 6, 26273-26273 (2016)

Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue

Jamieson SMF, et al.

Molecular Pain, 5(1), 66-66 (2009)

Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.

Bernard Nordlinger et al.

The Lancet. Oncology, 14(12), 1208-1215 (2013-10-15)

Previous results of the EORTC intergroup trial 40983 showed that perioperative chemotherapy with FOLFOX4 (folinic acid, fluorouracil, and oxaliplatin) increases progression-free survival (PFS) compared with surgery alone for patients with initially resectable liver metastases from colorectal cancer. Here we present

모든 관련된 서류 보기

문서

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Discover Bioactive Small Molecules for ADME/Tox

모두 보기

Oxaliplatin

Apoptosis inducer, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

양식

Quality Level

주관자

저장 온도

SMILES string

InChI

InChI key

관련 카테고리

설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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