O9387
Oxatomide
≥99%
동의어(들):
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C27H30N4O
CAS 번호:
Molecular Weight:
426.55
EC Number:
MDL number:
UNSPSC 코드:
51111800
PubChem Substance ID:
NACRES:
NA.77
Quality Level
분석
≥99%
양식
powder
색상
white
solubility
DMSO: soluble
ethanol: soluble
주관자
Johnson & Johnson
SMILES string
O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5
InChI
1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChI key
BAINIUMDFURPJM-UHFFFAOYSA-N
유전자 정보
human ... DRD3(1814)
일반 설명
Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.
생화학적/생리학적 작용
Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.
특징 및 장점
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Akihisa Goto et al.
Biological & pharmaceutical bulletin, 27(5), 684-690 (2004-05-11)
Oxatomide is an antiallergic drug used for the treatment of diseases mediated by type I allergy. Recently, it has been reported that terfenadine and astemizole, which have antiallergic actions similar to those of oxatomide, show side effects on the cardiovascular
Dong-Shang Lai et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 89(6), 589-598 (2002-12-19)
There has been no study comparing the long-term effects of ketotifen, oxatomide, and cetirizine for the treatment of perennial allergic rhinitis among children. We conducted a study to compare the efficacy of the three agents for the treatment of perennial
Mariko Domae et al.
The Journal of allergy and clinical immunology, 111(3), 567-572 (2003-03-19)
Eosinophils accumulated in sites of allergic inflammation are thought to play a crucial role in the pathogenesis of allergic disorders including asthma, allergic rhinitis, and atopic dermatitis, and tissue eosinophilia is attributable to increased eosinophil survival or decreased eosinophil apoptosis.
Hiroyuki Mizuguchi et al.
Pharmaceutics, 12(6) (2020-06-12)
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine is a non-sedative
H Kimata
European journal of clinical investigation, 33(6), 513-517 (2003-06-11)
Playing video games causes physical and psychological stress, including increased heart rate and blood pressure and aggression-related feelings. Use of mobile phones is very popular in Japan, and frequent ringing is a common and intrusive part of Japanese life. Atopic
문서
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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