L9756

(−)-Tetramisole hydrochloride

Name: (−)-Tetramisole hydrochloride
Brand: SIGMA

powder, ≥99% (GC)

동의어(들):

(S)-(−)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, L(−)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride, Levamisole hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₁H₁₂N₂S · HCl

CAS 번호:

16595-80-5

Molecular Weight:

240.75

Beilstein:

4358988

EC Number:

240-654-6

MDL number:

MFCD00012675

UNSPSC 코드:

12352202

PubChem Substance ID:

24278526

NACRES:

NA.77

주요 문서

모든 문서 보기

기술 서비스

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제품 이름

(−)-Tetramisole hydrochloride, ≥99% (GC)

생물학적 소스

synthetic (organic)

Quality Level

200

분석

≥99% (GC)

양식

powder

mp

228-230 °C

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

항생제 활성 스펙트럼

parasites

동작 모드

enzyme | inhibits

SMILES string

Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1

InChI key

LAZPBGZRMVRFKY-HNCPQSOCSA-N

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애플리케이션

Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor).
Intestinal alkaline phosphatases are only slightly inhibited.
Not for veterinary use.

생화학적/생리학적 작용

Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.

기타 정보

Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

픽토그램

GHS06

신호어

Danger

유해 및 위험 성명서

H301

예방조치 성명서

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

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Quantification of Tyrosine Hydroxylase and ErbB4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin.

Lei Guo et al.

Neuroscience bulletin, 35(2), 205-215 (2019-02-02)

The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown

Entosis Controls a Developmental Cell Clearance in C. elegans.

Yongchan Lee et al.

Cell reports, 26(12), 3212-3220 (2019-03-21)

Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to

Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase.

Lei Chang et al.

Bioorganic & medicinal chemistry letters, 21(8), 2297-2301 (2011-03-23)

Pathological calcifications induced by deposition of basic phosphate crystals or hydroxyapatite (HA) on soft tissues are a large family of diseases comprising of ankylosing spondylitis (AS), end-stage osteoarthritis (OA) and vascular calcification. High activity of tissue non-specific alkaline phosphatase (TNAP)

Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases.

Lina Li et al.

Bioorganic & medicinal chemistry, 17(20), 7290-7300 (2009-09-29)

Presence of basic calcium phosphate in knee joints of osteoarthritis patients could be prevented by inhibiting tissue non-specific alkaline phosphatase (TNAP) activity. Levamisole or the L stereoisomer of tetramisole (a known TNAP inhibitor) has been used as a treatment for

Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.

Agnes Cheong et al.

Development (Cambridge, England), 147(10) (2020-05-08)

Mitochondria are essential for energy production and although they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper function of the organelle. Although mutations in MRPs have been associated with human diseases, little is known

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프로토콜

Immunohistochemistry Procedure

Use this protocol to for the entire immunohistochemistry (IHC) procedure through staining and visualization of specific antigens in paraffin-embedded tissue sections.

(−)-Tetramisole hydrochloride

powder, ≥99% (GC)

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

생물학적 소스

Quality Level

분석

양식

mp

solubility

항생제 활성 스펙트럼

동작 모드

SMILES string

InChI

InChI key

설명

애플리케이션

생화학적/생리학적 작용

기타 정보

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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