L0668
Anti-LAMP2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
동의어(들):
Anti-CD107B, Anti-LGP110, Anti-Lysosomal Membrane Glycoprotein-type B (LGP-B), Anti-Lysosome-Associated Membrane Protein 2
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~110 kDa
종 반응성
human (predicted), mouse, rat
기술
indirect immunofluorescence: 10-20 μg/mL using rat NRK and mouse NIH3T3 cells
western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... LAMP2(3920)
mouse ... Lamp2(16784)
rat ... Lamp2(24944)
일반 설명
LAMP2 (lysosome-associated membrane protein 2) is a heavily glycosylated intrinsic protein (110kD) present in lysosomal membrane. The protein glycosylation is essential for its function to protect the lysosomal membrane from proteolytic enzymes. Anti-LAMP2 antibody can be used in western blotting. It can also be used as a lysosomal marker. Rabbit anti-LAMP2 antibody reacts specifically with LAMP2 of mouse and rat.
LAMP2 encodes a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome.
Lysosomal associated membrane protein 2 (LAMP2) gene is located on human chromosome Xq24. LAMP2 is majorly expressed in lysosomes. It has three isoforms, that is LAMP2A, LAMP2B and LAMP2C.
면역원
synthetic peptide corresponding to amino acid residues 404-415 of mouse LAMP2 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in rat and differs by two amino acids in human.
애플리케이션
Anti-LAMP2 antibody can be used in immunofluorescence and immunoblotting
Anti-LAMP2 antibody produced in rabbit has been used in immunohistochemical analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
생화학적/생리학적 작용
Lysosomal associated membrane protein 2 (LAMP2) promotes cell-cell adhesion. It maintains cellular homeostasis and stress.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Suraj Dixit et al.
Molecular pharmaceutics, 12(9), 3250-3260 (2015-07-23)
Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epidermal growth
Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively.
Mattei MG, et al.
The Journal of Biological Chemistry, 265(13), 7548-7551 (1990)
Olga A Mareninova et al.
Cellular and molecular gastroenterology and hepatology, 1(6), 678-694 (2015-12-23)
The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, we investigate the role of lysosome associated membrane proteins (LAMPs) in pancreatitis.
Acute alloxan renal toxicity in the rat initially causes degeneration of thick ascending limbs of Henle
Terayama Y, et al.
Journal of Toxicologic Pathology (2016)
Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
Peschel A, et al.
Journal of the American Society of Nephrology, 25(3), 455-463 (2014)
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