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Merck

H5388

Sigma-Aldrich

Hyaluronic acid sodium salt from rooster comb

avian glycosaminoglycan polysaccharide

동의어(들):

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

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제품정보 (DICE 배송 시 비용 별도)

CAS 번호:
MDL number:
UNSPSC 코드:
12352201
PubChem Substance ID:
NACRES:
NA.25
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생물학적 소스

chicken (rooster comb)

Quality Level

양식

powder

불순물

≤2% protein (Lowry)

색상

white

solubility

water: ~5 g/L

양이온 미량물

Na: 3-7%

저장 온도

−20°C

SMILES string

[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

애플리케이션

Hyaluronic acid sodium salt from rooster comb has been used:
  • as a component of bi-layer gelatin scaffold
  • as a vehicle for release of gentamicin during left ear surgery in guinea pigs
  • in hyaluronic acid binding assay in human embryonic kidney cell line 293T

생화학적/생리학적 작용

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Hyaluronic acid is a polysaccharide present in the skin, connective tissue, vitreous humor and synovial fluid. It is essential for tissue hydration and functions to regenerate skin post injury or wounds. Hyaluronic acid, apart from having dermatologic and ophthalmologic applications, serves as a drug delivery vehicle. Hyaluronic acid also exhibits antioxidant and antiglycation properties.

기타 정보

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Hyaluronic acid enhances gene delivery into the cochlea
Shibata SB, et al.
Human Gene Therapy, 23(3), 302-310 (2011)
Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities
Hafsa J, et al.
Pharmaceutical biology, 55(1), 156-163 (2017)
Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity
Ramakrishna S, et al.
PLoS ONE, 7(5), e37772-e37772 (2012)
Extraction, purification and characterization of hyaluronic acid from Rooster comb
Kulkarni SS, et al.
Journal of Applied and Natural Science, 10(1), 313-315 (2018)
Purification and characterization of hyaluronic acid from chicken combs
Rosa CS, et al.
Ciencia Rural, 42(9), 1682-1687 (2012)

문서

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

프로토콜

To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.

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