D1916

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

Name: 5,6-Dichlorobenzimidazole 1-β-<SC>D</SC>-ribofuranoside
Brand: SIGMA

≥98% (HPLC), powder, RNA synthesis inhibitor

동의어(들):

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB

로그인조직 및 계약 가격 보기

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₂Cl₂N₂O₄

CAS 번호:

53-85-0

Molecular Weight:

319.14

Beilstein:

39123

MDL number:

MFCD00036785

UNSPSC 코드:

12352200

eCl@ss:

32151902

PubChem Substance ID:

24278361

NACRES:

NA.77

주요 문서

모든 문서 보기

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

제품 이름

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside,

양식

powder

Quality Level

200

저장 온도

−20°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23

InChI

1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1

InChI key

XHSQDZXAVJRBMX-DDHJBXDOSA-N

유전자 정보

human ... CSNK2A1(1457), CSNK2B(1460)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:

as an inhibitor of RNA polymerase II in mouse melanoma cells
for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
in the inhibition of interleukin-2 gene transcription in Jurkat cells

생화학적/생리학적 작용

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.

Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

Yamaguchi Y, et al.

Cell, 97(1), 41-51 (1999)

Rates of in situ transcription and splicing in large human genes

Singh J and Padgett RA

Nature Structural and Molecular Biology, 16(11), 1128-1128 (2009)

Transcriptional regulation of interleukin-2 gene expression is impaired by copper deficiency in Jurkat human T lymphocytes

Hopkins RG and Failla ML

The Journal of Nutrition, 129(3), 596-601 (1999)

Androgen receptor-mediated growth suppression of HPr-1AR and PC3-Lenti-AR prostate epithelial cells

Kim YC, et al.

PLoS ONE, 10(9), e0138286-e0138286 (2015)

Exploiting native forces to capture chromosome conformation in mammalian cell nuclei.

Lilija Brant et al.

Molecular systems biology, 12(12), 891-891 (2016-12-13)

Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function. Chromosome conformation capture (3C) technology has significantly advanced our understanding of this structure-to-function relationship. However, all

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

≥98% (HPLC), powder, RNA synthesis inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

양식

Quality Level

저장 온도

SMILES string

InChI

InChI key

유전자 정보

관련 카테고리

설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

안전성 정보

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

관련 참고 논문

관련 참고 프로토콜

문서

관련 콘텐츠

기술 서비스