C8221

Caffeic acid phenethyl ester

Name: Caffeic acid phenethyl ester
Brand: SIGMA

synthetic, ≥97% (HPLC), Nuclear transcription factor NF-κB inhibitor, powder

동의어(들):

CAPE

로그인조직 및 계약 가격 보기

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₇H₁₆O₄

CAS 번호:

104594-70-9

Molecular Weight:

284.31

MDL number:

MFCD00866470

UNSPSC 코드:

12352108

PubChem Substance ID:

24278341

NACRES:

NA.77

주요 문서

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제품 이름

Caffeic acid phenethyl ester, ≥97% (HPLC), powder

생물학적 소스

synthetic

Quality Level

200

분석

≥97% (HPLC)

양식

powder

저장 조건

protect from light

색상

off-white

solubility

ethyl acetate: 50 mg/mL
DMSO: soluble
ethanol: soluble

저장 온도

−20°C

SMILES string

Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O

InChI

1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

InChI key

SWUARLUWKZWEBQ-VQHVLOKHSA-N

유전자 정보

human ... NFKB2(4791)

애플리케이션

Caffeic acid phenethyl ester (CAPE) has been used to determine the effect of CAPE in hyperthyroidism, as a component of culture media to measure the cytotoxicity of breast cancer cell line MDA-MB-231, to study its effects on amiodarone-induced pulmonary fibrosis in rats.

생화학적/생리학적 작용

CAPE exhibits several properties such as anticarcinogenic, immunomodulatory activities, antioxidant, antiviral, anti-inflammatory, hypoglycaemic effect, cardioprotective and inhibits gastric secretion. It also has an inhibitory effect on fibroblasts growth factor type 2 (FGF-2), a tumor growth factor in breast cancer.

Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells.

Z Z Su et al.

Anticancer research, 15(5B), 1841-1848 (1995-09-01)

The active component of the folk medicine propolis, caffeic acid phenethyl ester (CAPE), displays selective toxicity toward cloned rat embryo fibroblast (CREF) cells transformed by a spectrum of diverse acting oncogenes. Identification of the mode of action of CAPE should

Strategies for elevating hematopoietic stem cells expansion and engraftment capacity.

Mehdi Derakhshani et al.

Life sciences, 232, 116598-116598 (2019-06-28)

Hematopoietic stem cells (HSCs) are a rare cell population in adult bone marrow, mobilized peripheral blood, and umbilical cord blood possessing self-renewal and differentiation capability into a full spectrum of blood cells. Bone marrow HSC transplantation has been considered as

Protective effect of caffeic acid phenethyl ester (CAPE) on amiodarone-induced pulmonary fibrosisin rat

Zaeemzadeh N, et al.

Iranian Journal of Pharmaceutical Research : IJPR, 10(2), 321-321 (2011)

Migration rate inhibition of breast cancer cells treated by caffeic acid and caffeic acid phenethyl ester: an in vitro comparison study

Kabala-Dzik A, et al.

Nutrients, 9(10), 1144-1144 (2017)

Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed rat embryo cells correlate directly with transformation progression.

Z Z Su et al.

Cancer research, 54(7), 1865-1870 (1994-04-01)

The active component of the honeybee hive product propolis, caffeic acid phenethyl ester (CAPE), induces a selective growth suppressive and toxic effect toward cloned rat embryo fibroblast cells transformed by adenovirus type 5 (Ad5) or the Ad5 E1A transforming gene

모든 관련된 서류 보기

문서

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Caffeic acid phenethyl ester

synthetic, ≥97% (HPLC), Nuclear transcription factor NF-κB inhibitor, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

생물학적 소스

Quality Level

분석

양식

저장 조건

색상

solubility

저장 온도

SMILES string

InChI

InChI key

유전자 정보

관련 카테고리

설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

안전성 정보

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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