C3865
Anti-N-Cadherin antibody, Mouse monoclonal
clone GC-4, purified from hybridoma cell culture
동의어(들):
Anti-A-CAM, Anti-A-Cell Adhesion Molecule
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
GC-4, monoclonal
양식
buffered aqueous solution
분자량
antigen 135 kDa
종 반응성
chicken, monkey, mouse, human, rabbit, rat
기술
electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
동형
IgG1
UniProt 수납 번호
응용 분야
research pathology
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)
관련 카테고리
일반 설명
N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.
애플리케이션
Anti-N-Cadherin antibody is suitable for the following procedures:
- electron microscopy
- flow cytometry
- immunocytochemistry
- immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
- western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts
생화학적/생리학적 작용
CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.
물리적 형태
0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
기타 정보
Clone GC-4 is also known as GB-9.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves
Priscilla Y Hwang et al.
Cellular and molecular bioengineering, 8(1), 51-62 (2015-04-08)
Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with strong cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with aging-associated changes in
Emilie Duchalais et al.
Cellular and molecular gastroenterology and hepatology, 5(1), 31-49 (2017-12-01)
In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells.
Gang Chen et al.
Nature communications, 7, 12531-12531 (2016-08-20)
Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duration of pain. Intrathecal injection of the mu-opioid
Telomerase and N-Cadherin Differential Importance in Adrenocortical Cancers and Adenomas.
Pereira SS, et al.
Journal of Cellular Biochemistry, 118(8), 2064-2071 (2017)
Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.
Nelson ER, et al.
Oncotarget, 7(51), 84030-84030 (2016)
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