C3019
Coenzyme A trilithium salt
≥93%
동의어(들):
CoA Li3
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C21H33Li3N7O16P3S
CAS 번호:
Molecular Weight:
785.33
EC Number:
MDL number:
UNSPSC 코드:
41106305
PubChem Substance ID:
NACRES:
NA.51
Quality Level
분석
≥93%
양식
powder
저장 온도
−20°C
SMILES string
[Li+].[Li+].[Li+].CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16?,20-;;;/m1.../s1
InChI key
QSCBPHBAFBVXRK-HJKJOZROSA-K
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일반 설명
Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.
애플리케이션
Coenzyme A trilithium salt has been used:
- in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation
- as a cofactor in JNADH and JNADPH production assay
- in the labeling of Alexa647 (AF647) probe
생화학적/생리학적 작용
Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. Acyl CoA accumulation is implicated in metabolic disorders and may indirectly lead to the pathogenesis associated with carbon-induced mitochondrial stress heart failure, diabetes and obesity.
기타 정보
For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Structural basis for acyl-group discrimination by human Gcn5L2
Ringel AE and Wolberger C
Acta crystallographica. Section D, Structural biology, 72(7), 841-848 (2016)
Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
Lu X, et al.
Nature Communications, 10(1), 1378-1378 (2019)
Pantothenate kinase regulation of the intracellular concentration of coenzyme A
Rock CO, et al.
The Journal of biological chemistry, 275(2), 1377-1383 (2000)
Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics
Fisher-Wellman KH, et al.
Cell Reports, 26(6), 1557-1572 (2019)
Jessica P Kuppan et al.
eLife, 10 (2021-09-30)
The complement system is a critical host defense against infection, playing a protective role that can also enhance disease if dysregulated. Although many consequences of complement activation during viral infection are well established, mechanisms that determine the extent to which
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