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Merck

B2680

Sigma-Aldrich

BMP4, human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

동의어(들):

Bone Morphogenetic Protein 4 human, BMP-4

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

MDL number:
MFCD01867024
UNSPSC 코드:
12352202
NACRES:
NA.32

주요 문서

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제품 이름

Bone Morphogenetic Protein 4 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

생물학적 소스

human

Quality Level

200

재조합

expressed in NSO cells

분석

>95% (SDS-PAGE)

양식

lyophilized powder

효능

10-30 ng/mL ED50

분자량

monomer calculated mol wt 13 kDa
 ~22 kDa by SDS-PAGE

포장

pkg of 10 μg

저장 조건

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

기술

cell culture | mammalian: suitable

불순물

<1 EU/mg Endotoxin level (LAL test)

UniProt 수납 번호

P12644

저장 온도

−20°C

유전자 정보

human ... BMP4(652)

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관련 카테고리

생화학적/생리학적 작용

Cellular responses to BMP-4 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF A by osteoblasts. Mature human and mouse BMP-4 demonstrates 98% and 100% homology, respectively, to mature rat BMP-4.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of cytokine.

분석 메모

The biological activity is measured by its ability to induce alkaline phosphatase production by C2C12 myoblasts.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
MKCL9512
MKCD9024
MKBT1873V
120M1905
031M1435

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Martine M L Deckers et al.
Endocrinology, 143(4), 1545-1553 (2002-03-19)
During bone formation and fracture healing there is a cross-talk between endothelial cells and osteoblasts. We previously showed that vascular endothelial growth factor A (VEGF-A) might be an important factor in this cross-talk, as osteoblast-like cells produce this angiogenic factor
M Kawabata et al.
Cytokine & growth factor reviews, 9(1), 49-61 (1998-08-28)
Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which are members of the transforming growth factor-beta (TGF-beta) superfamily. Activities of BMPs are extracellularly regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of serine-threonine kinase receptors, type
Thorsten Pfirrmann et al.
Human molecular genetics, 24(11), 3119-3132 (2015-02-26)
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
Silvia Calpe et al.
Molecular cancer therapeutics, 14(11), 2527-2540 (2015-09-10)
Bone morphogenetic proteins (BMP) have important but distinct roles in tissue homeostasis and disease, including carcinogenesis and tumor progression. A large number of BMP inhibitors are available to study BMP function; however, as most of these antagonists are promiscuous, evaluating
Meike Simann et al.
Bone, 78, 102-113 (2015-05-12)
Heparins are broadly used for the prevention and treatment of thrombosis and embolism. Yet, osteoporosis is considered to be a severe side effect in up to one third of all patients on long-term treatment. However, the mechanisms underlying this clinical
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