A3262
Adenosine 3′,5′-cyclic monophosphate tris salt
≥97% (HPLC), synthetic, powder
동의어(들):
cAMP, cyclic AMP
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H12N5O6P · C4H11NO3
CAS 번호:
Molecular Weight:
450.34
MDL number:
UNSPSC 코드:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
제품 이름
Adenosine 3′,5′-cyclic monophosphate tris salt, ≥97% (HPLC), powder
생물학적 소스
synthetic
Quality Level
분석
≥97% (HPLC)
양식
powder
색상
white
solubility
H2O: 100 mg/mL
저장 온도
−20°C
SMILES string
NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1
InChI key
CLDDYJFNXTUHIN-MCDZGGTQSA-N
관련 카테고리
일반 설명
Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays. Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production. Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.
애플리케이션
Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture and induced neural stem cells (iNSCs). It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.
생화학적/생리학적 작용
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors
Tang X, et al.
Stem Cell Research, 16(2), 236-242 (2016)
Alexander Mueller et al.
Pain, 160(8), 1766-1780 (2019-07-25)
Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, postsurgical pain continues to be a frequent and undermanaged condition. Here, we investigate the analgesic potential of pharmacological NaV1.7 inhibition in a
Cyclic AMP: master regulator of innate immune cell function
Serezani CH, et al.
American Journal of Respiratory Cell and Molecular Biology, 39(2), 127-132 (2008)
Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging
Harada K, et al.
Scientific reports, 7(1), 7351-7351 (2017)
Local cAMP signaling in disease at a glance
Gold MG, et al.
Journal of Cell Science, 126(20), 4537-4542 (2013)
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