A0326

(S)-AMPA

Name: (<I>S</I>)-AMPA
Brand: SIGMA

≥97%, AMPA receptor agonist, powder

동의어(들):

(S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₇H₁₀N₂O₄

CAS 번호:

83643-88-3

Molecular Weight:

186.17

MDL number:

MFCD00672630

UNSPSC 코드:

12352200

PubChem Substance ID:

24890421

NACRES:

NA.77

주요 문서

모든 문서 보기

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제품 이름

(S)-AMPA, ≥97%

Quality Level

100

분석

≥97%

양식

powder

SMILES string

Cc1onc(O)c1C[C@H](N)C(O)=O

InChI

1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1

InChI key

UUDAMDVQRQNNHZ-YFKPBYRVSA-N

유전자 정보

human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897)
mouse ... Gria1(14799)
rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grin2b(24410), Grm6(24419)

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일반 설명

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).

애플리케이션

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.

(S)-AMPA has been used to selectively eliminate the neural cochlear component of adult barn owls by destroying afferent synapses.

생화학적/생리학적 작용

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

Potent agonist at the AMPA subclass of ionotropic glutamate receptors; active enantiomer.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Redefining the classification of AMPA-selective ionotropic glutamate receptors.

Derek Bowie

The Journal of physiology, 590(1), 49-61 (2011-11-23)

AMPA-type ionotropic glutamate receptors (iGluRs) represent the major excitatory neurotransmitter receptor in the developing and adult vertebrate CNS. They are crucial for the normal hardwiring of glutamatergic circuits but also fine tune synaptic strength by cycling into and out of

Interneuron Diversity series: Fast in, fast out-temporal and spatial signal processing in hippocampal interneurons

Jonas P, et al.

Trends in Neurosciences, 27(1), 30-40 (2004)

Evoked cochlear potentials in the barn owl

Koppl C and Gleich O

J. Comp. Physiol., 193(6), 601-612 (2007)

Cornichons control ER export of AMPA receptors to regulate synaptic excitability.

Penelope J Brockie et al.

Neuron, 80(1), 129-142 (2013-10-08)

The strength of synaptic communication at central synapses depends on the number of ionotropic glutamate receptors, particularly the class gated by the agonist AMPA (AMPARs). Cornichon proteins, evolutionarily conserved endoplasmic reticulum cargo adaptors, modify the properties of vertebrate AMPARs when

Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors.

J Lauridsen et al.

Journal of medicinal chemistry, 28(5), 668-672 (1985-05-01)

The syntheses of (RS)-alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionic acid (9, ATPA), (alpha-RS, beta-RS)-alpha-amino-beta-methyl-3-hydroxy-5-isoxazolepropionic acid (8), (RS)-alpha-amino-3-hydroxy-5-isoxazolebutyric acid (15a), and (RS)-alpha-amino-3-hydroxy-5-isoxazolevaleric acid (15b) are described. The compounds were tested in vitro together with (RS)-alpha-amino-3-hydroxy-5-(bromomethyl)-4-isoxazolepropionic acid (ABPA) as inhibitors of the binding of radioactive-labeled (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

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(S)-AMPA

≥97%, AMPA receptor agonist, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

Quality Level

분석

양식

SMILES string

InChI

InChI key

유전자 정보

관련 카테고리

설명

일반 설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

안전성 정보

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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