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I1633

Insulin chain A oxidized ammonium salt from bovine pancreas

Name: Insulin chain A oxidized ammonium salt from bovine pancreas
Brand: SIGMA

≥80% (HPLC), powder

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

C₉₇H₁₅₁N₂₅O₄₆S₄ · (NH₃)_x

CAS 번호:

77282-71-4

Molecular Weight:

2531.64 (free acid basis)

UNSPSC Code:

12352202

NACRES:

NA.32

Biological source:

bovine

Form:

powder

Assay:

≥80% (HPLC)

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도움 문의

속성

biological source

bovine

Quality Level

200

sterility

non-sterile

assay

≥80% (HPLC)

form

powder

UniProt accession no.

P01317

shipped in

ambient

storage temp.

−20°C

SMILES string

[S](=O)(=O)(O)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@H](CC)C)C(C)C)CCC(=O)O)CCC(=O)N)C[S](=O)(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C[S](=O)(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)

InChI

1S/C97H151N25O46S4/c1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-171(163,164)165)93(151)118-64(38-169(157,158)159)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-172(166,167)168)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-170(160,161)162)91(149)113-61(97(155)156)34-71(102)130/h13-20,42-47,52-67,75-77,123-126H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)(H,157,158,159)(H,160,161,162)(H,163,164,165)(H,166,167,168)/t46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m0/s1

InChI key

WYHLQQAVJPCFKN-DQLAGKHYSA-N

Gene Information

cow ... INS(280829)

설명

Biochem/physiol Actions

Human insulin is made up of 51 amino acids. It consists of two peptide chains, 21 amino acids make up A-chain and chain B contains 31 amino acids. The two chains are linked together by a disulfide bond, to form a classical insulin fold with three α helices, chain A having two and one in chain B.

Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids. It inhibits the breakdown of glycogen, protein, and fat. The α chain contains an intrachain disulfide bond.

Preparation Note

Prepared by a modification of Sanger, F., et al., Biochem. J., 44, 126 (1949).

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Insulin analog with additional disulfide bond has increased stability and preserved activity.

Tine N Vinther et al.

Protein science : a publication of the Protein Society, 22(3), 296-305 (2013-01-03)

Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might be hypothesized that

국제 무역 품목 번호

SKU	GTIN
I1633-50MG	04061832820668
I1633-10MG	04061832820651
I1633-1MG	04061833847879
I1633-5MG	04061832820675