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A211200

DMT-2′Fluoro-dA(bz) Phosphoramidite

Name: DMT-2′Fluoro-dA(bz) Phosphoramidite
Brand: SIGMA

동의어(들):

DMT-2′Fluoro-dA(bz) Amidite

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크기 선택

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄₇H₅₁FN₇O₇P

Molecular Weight:

875.92

NACRES:

NA.51

PubChem Substance ID:

329770749

UNSPSC Code:

41116105

MDL number:

MFCD12912392

Assay:

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

Biological source:

non-animal source (no BSE/TSE risk)

Form:

powder

Storage temp.:

−20°C

기술 서비스

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도움 문의

속성

biological source

non-animal source (no BSE/TSE risk)

Quality Level

300

product line

Proligo Reagents

assay

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

form

powder

technique(s)

oligo synthesis: suitable

impurities

≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content

color

white to off-white

λ

conforms (UV/VIS Identity)

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

nucleoside profile

base: deoxyadenosine
base protecting group: benzoyl
2' protecting group: fluoro
5' protecting group: DMT
deprotection: fast/standard

storage temp.

−20°C

SMILES string

CC(C)N(C(C)C)P(OCCC#N)O[C@H]([C@H](O1)COC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4)[C@@H](F)[C@@H]1N5C6=NC=NC(NC(C7=CC=CC=C7)=O)=C6N=C5

InChI

1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1

InChI key

VCCMVPDSLHFCBB-MSIRFHFKSA-N

설명

General description

DMT-2′Fluoro-dA(bz) Phosphoramidite is a 2′Fluoro phosphoramidite that is used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.

Its key features include,

Can be employed together with DNA or RNA phosphoramidites
Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C
Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers)
Consistent lot-to-lot high purity and performance
Manufactured under a certified ISO 9001 quality system

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c