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A211100

DMT-2′O-Methyl-rA(bz) Phosphoramidite

Name: DMT-2′O-Methyl-rA(bz) Phosphoramidite
Brand: SIGMA

동의어(들):

DMT-2′-O-Me-rA(bz) amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄₈H₅₄N₇O₈P

CAS 번호:

110782-31-5

Molecular Weight:

887.96

NACRES:

NA.51

PubChem Substance ID:

329770740

UNSPSC Code:

41116105

MDL number:

MFCD00792622

Assay:

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

Biological source:

non-animal source (no BSE/TSE risk)

Form:

powder

Storage temp.:

-10 to -25°C

기술 서비스

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도움 문의

속성

biological source

non-animal source (no BSE/TSE risk)

Quality Level

300

product line

Proligo Reagents

assay

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

form

powder

technique(s)

oligo synthesis: suitable

impurities

≤0.1% single unspecified Impurity (reversed phase HPLC), ≤0.3% mA2 (reversed phase HPLC, Hydrolysate), ≤0.3% mA3 (reversed phase HPLC, DMT-rA(bz)me), ≤0.3 wt. % water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR), ≤1.0% mA1 (reversed phase HPLC, DMT-rA(bz)me-DMT), ≤3 wt. % residual Solvent content

color

white to off-white

λ

conforms (UV/VIS Identity)

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

nucleoside profile

base: adenosine
base protecting group: benzoyl
2' protecting group: methyl
5' protecting group: DMT
deprotection: standard

storage temp.

-10 to -25°C

SMILES string

CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c3ccc(OC)cc3)c4ccc(OC)cc4)O[C@H]1n5cnc6c(NC(=O)c7ccccc7)ncnc56

InChI

1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

InChI key

AZCGOTUYEPXHMJ-PSVHYZMASA-N

설명

General description

DMT-2′O-Methyl-rA(bz) Phosphoramidite belongs to the class of 2′O-Methyl RNA Phosphoramidites. 2′O-Methyl RNA monomers are compatible with fast deprotection schemes that are based on the application of aliphatic amines, such as methylamine. 2′O-Methyl RNA is a nucleic acid analog that is characterized by the exceptional hybridization properties that it imparts with complementary DNA or RNA, as well as increased stability against enzymatic degradation compared to natural nucleic acids. 2′O-Methyl RNA monomers feature methoxy groups at the 2′-position. The methoxy groups are perfectly stable in all conditions employed in the assembly of oligonucleotides by automated phosphoramidite synthesis, and in all standard alkaline deprotection conditions.

Application

DMT-2′O-Methyl-rA(bz) Phosphoramidite is suitable for use in the preparation of oligonucleotide probes.

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c