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Merck

85558

Sigma-Aldrich

Spermidine

BioUltra, Molecular Biology, ≥99.5% (GC)

동의어(들):

SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS 번호:
124-20-9
Molecular Weight:
145.25
Beilstein:
1698591
EC Number:
204-689-0
MDL number:
MFCD00008229
UNSPSC 코드:
12352116
PubChem Substance ID:
57653053
NACRES:
NA.26

주요 문서

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기술 서비스
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도움 문의

Grade

Molecular Biology

Quality Level

200

제품 라인

BioUltra

분석

≥99.5% (GC)

저장 조건

(Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)

기술

ChIP: suitable
buffer exchange: suitable

불순물

DNases, none detected
 RNases, none detected
 insoluble matter, passes filter test
 phosphatases, none detected
 proteases, none detected

refractive index

n20/D 1.479 (lit.)

pH

12.0-13.5 (25 °C, 1 M in H2O)

solubility

H2O: 1 M at 20 °C, clear, colorless

density

0.925 g/mL at 25 °C (lit.)

음이온 미량물

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

양이온 미량물

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV 흡수

λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05

SMILES string

NCCCCNCCCN

적합성

suitable for molecular biology

응용 분야

advanced drug delivery
genomic analysis

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

유전자 정보

rat ... Ppm1a(24666)

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관련 카테고리

일반 설명

Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

애플리케이션

Spermidine has been used:
  • as a component of chromosome isolation buffer
  • as a component of transcription buffer
  • as a component of homogenization buffer

생화학적/생리학적 작용

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.

특징 및 장점

  • Versatile and adaptable for a wide variety of laboratory and research applications
  • Suitable for Molecular Biology and Biochemical research
  • Free from DNase, RNase, NICKase, and protease
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
  • Tested for trace levels of Anions and Cations

분석 메모

liquid or solid

기타 정보

For additional information on our range of Biochemicals, please complete this form.
In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants

면책조항

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

픽토그램

Corrosion
GHS05

신호어

Danger

유해 및 위험 성명서

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

233.6 °F - closed cup

Flash Point (°C)

112 °C - closed cup

개인 보호 장비

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCH0584
BCCG7056
BCCG6243
BCCG4247
BCCG3991

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COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Induction of Autophagy and Apoptosis in Melanoma Treated With Palladacycle Complexes
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 231-247 (2016)
Krug, M.S. et al.
Methods in Enzymology, 152, 321-321 (1987)
Sample Preparation of Telomerase Subunits for Crystallization
Huang J, et al.
Bio-protocol, 5(16) (2015)
Biochemical Isolation of Myonuclei from Mouse Skeletal Muscle Tissue
Cutler AA, et al.
Bio-protocol, 7(24) (2017)
Restriction Endonucleases and Modification Methylases
Enzymology Primer for Recombinant DNA Technology, 233-306 (1996)
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