52423
Dextran sulfate sodium salt from Leuconostoc spp.
low sulfate content, Mr ~40,000
생물학적 소스
(Leuconostoc spp)
Quality Level
양식
powder
품질
low sulfate content
분자량
Mr ~40,000
구성
Sulfur Content, 8-13%
손실
≤10% loss on drying
색상
white to off-white
유용한 pH 범위
6.0-8 (10 g/L)
solubility
H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow
저장 온도
room temp
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일반 설명
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.
애플리케이션
Dextran sulfate increases binding of epithelial cells and lymphocytes to extracellular matrix proteins including fibronectin and laminin. In addition, dextran sulfate altered expreβion of cell surface receptors integrins.
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
제조 메모
Sigma dextrans are derived from Leuconostoc mesenteroides.
기타 정보
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
J Ni et al.
Gut, 39(2), 234-241 (1996-08-01)
The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial
Jiang-Hua Liu et al.
Disease models & mechanisms, 13(11) (2020-10-10)
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and
문서
Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.
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