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Merck

PHR1393

Supelco

Ampicillin Trihydrate

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Ampicillin trihydrate, D-(−)-α-Aminobenzylpenicillin

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C16H19N3O4S · 3H2O
CAS 번호:
7177-48-2
Molecular Weight:
403.45
Beilstein:
5399534
EC Number:
200-709-7
MDL number:
MFCD00072036
UNSPSC 코드:
41116107
PubChem Substance ID:
329823367
NACRES:
NA.24

주요 문서

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기술 서비스
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도움 문의

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

USP 1033000/1033407
traceable to Ph. Eur. A1000000

API family

ampicillin

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

mp

198-200 °C (dec.) (lit.)

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(O)=O

InChI

1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1

InChI key

RXDALBZNGVATNY-CWLIKTDRSA-N

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관련 카테고리

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

애플리케이션

Ampicillin trihydrate may be used as an analytical reference standard for the determination of ampicillin in plasma samples and pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

기타 정보

To see an example of a Certificate of Analysis for this material enter LRAA1900 in the slot below. This is an example certificate only and may not be the lot that you receive.

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H315,H317,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Determination of amoxicillin, ampicillin, and penicillin G using a flow injection analysis method with chemiluminescence detection.
Chivulescu AI, et al.
Rev. Roum. Chim., 56(3), 247-254 (2011)
Determination of ampicillin in human plasma by high-performance liquid chromatography using ultraviolet detection.
Akhtar MJ, et al.
Journal of Pharmaceutical and Biomedical Analysis, 11(4-5), 375-378 (1993)
Felipe H Coutinho et al.
Microbial ecology, 68(3), 441-452 (2014-05-14)
Bacterial resistance to antibiotics has become a public health issue. Over the years, pathogenic organisms with resistance traits have been studied due to the threat they pose to human well-being. However, several studies raised awareness to the often disregarded importance
Hazem E Ghoneim et al.
The Journal of infectious diseases, 209(9), 1459-1468 (2013-11-26)
Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute to these poor outcomes. Using Streptococcus pneumoniae in
Yuraporn Sahasakul et al.
The British journal of nutrition, 112(3), 408-415 (2014-06-17)
Lactobacilli are indigenous microbes of the stomach of rodents, with much lower numbers being present in mice fed a purified diet than in those fed a non-purified diet. We postulated that gastric emptying (GE) is responsible for the different colonisation
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