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Merck

PHR1379

Supelco

Atropine Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
(C17H23NO3)2 · H2SO4 · H2O
CAS 번호:
5908-99-6
Molecular Weight:
694.83
Beilstein:
6109275
EC Number:
200-235-0
MDL number:
MFCD00074815
UNSPSC 코드:
41116107
PubChem Substance ID:
329823356
NACRES:
NA.24

주요 문서

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기술 서비스
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도움 문의

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. A1400000
traceable to USP 1045009

API family

atropine

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

mp

189-192 °C (A) (lit.)

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

유전자 정보

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)

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관련 카테고리

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Atropine Sulfate is an alkaloid extracted from belladonna herb. It is a cholinergic drug, administered as an anti-arrhythmic medicine.

애플리케이션

Atropine Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrophoresis and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

기타 정보

To see an example of a Certificate of Analysis for this material enter LRAC4087 in the slot below. This is an example certificate only and may not be the lot that you receive.

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H300 + H330

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Determination of atropine sulfate using a novel sensitive DNA-biosensor based on its interaction on a modified pencil graphite electrode.
Ensafi AA, et al.
Talanta, 131, 149-155 (2015)
Development and validation of a capillary zone electrophoresis method for the determination of atropine, homatropine and scopolamine in ophthalmic solutions.
Cherkaoui S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 696(2), 283-290 (1997)
Determination of atropine in pharmaceutical preparations by liquid chromatography with fluorescence detection.
Takahashi M, et al.
Journal of Chromatography A, 775(1-2), 137-141 (1997)
LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.
Ceyhan T, et al.
Journal of Pharmaceutical and Biomedical Analysis, 25(3-4), 399-406 (2001)
Miklós Palotai et al.
Neurochemical research, 39(8), 1477-1483 (2014-06-05)
The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depression, reward and drug addiction, learning and memory. Previous studies demonstrated that the NOP-receptor
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