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Merck

PHR1144

Supelco

Diclofenac sodium salt

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C14H10Cl2NNaO2
CAS 번호:
15307-79-6
Molecular Weight:
318.13
EC Number:
239-346-4
MDL number:
MFCD00082251
UNSPSC 코드:
41116107
PubChem Substance ID:
329823164
NACRES:
NA.24

주요 문서

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기술 서비스
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도움 문의

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. S0765000
traceable to USP 118880

API family

diclofenac

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-30°C

SMILES string

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KPHWPUGNDIVLNH-UHFFFAOYSA-M

유전자 정보

human ... PTGS1(5742), PTGS2(5743)

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관련 카테고리

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diclofenac is a derivative of benzeneacetic acid. It is categorized under the class of non-steroidal anti-inflammatory drugs (NSAIDs). It shows inflammatory, analgesic and antipyretic activities.

애플리케이션

Diclofenac sodium salt may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

분석 메모

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

기타 정보

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC1513 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

픽토그램

Skull and crossbonesHealth hazardEnvironment
GHS06,GHS08,GHS09

신호어

Danger

유해 및 위험 성명서

H301,H361d,H372,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

High Performance Thin Layer Chromatographic Method for the Determination of Diclofenac Sodium in Pharmaceutical Formulations
Thongchai W, et al.
Chiang Mai Journal of Science, 33(1) (2006)
Determination of diclofenac salts in pharmaceutical formulations
Bucci R, et al.
Fresenius Journal of Analytical Chemistry, 362(7-8), 577-582 (1998)
Simultaneous determination of methylparaben, propylparaben, sodium diclofenac and its degradation product in a topical emulgel by reversed-phase liquid chromatography
Hajkova R, et al.
Analytica Chimica Acta, 467(1), 91-96 (2002)
Alison E M Vickers et al.
International journal of molecular sciences, 19(12) (2018-12-24)
Human liver slice function was stressed by daily dosing of acetaminophen (APAP) or diclofenac (DCF) to investigate injury and repair. Initially, untreated human liver and kidney slices were evaluated with the global human U133A array to assess the extended culture
Shahinaze A Fouad et al.
International journal of pharmaceutics, 453(2), 569-578 (2013-06-26)
Microemulsion (ME) and poloxamer microemulsion-based gel (PMBG) were developed and optimized to enhance transport of diclofenac epolamine (DE) into the skin forming in-skin drug depot for sustained transdermal delivery of drug. D-optimal mixture experimental design was applied to optimize ME
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문서

UHPLC Analysis of Diclofenac in Gel using a Monolithic Silica Column

A comparative UHPLC analysis of diclofenac sodium in gel using Chromolith® HighResolution RP-18 endcapped 100 x 2 mm I.D column and FPP 1.7 µm hybrid silica C18 100 x 2.1 mm I.D column with UV and MS detection.

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