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PHR2050

Amlodipine Related Compound A

Name: Amlodipine Related Compound A
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

3-Ethyl 5-methyl [2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-3,5-pyridinedicarboxylate] fumarate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₂₃ClN₂O₅ · C₄H₄O₄

CAS 번호:

2138811-33-1

Molecular Weight:

522.93

UNSPSC Code:

41116107

NACRES:

NA.24

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속성

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1029512

API family

amlodipine

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

application(s)

pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

Clc1c(cccc1)c2c(c(nc(c2C(=O)OC)C)COCCN)C(=O)OCC.OC(=O)\C=C\C(=O)O

InChI key

BWAQLJHPVPAANJ-WLHGVMLRSA-N

설명

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the long-acting calcium channel blocker, amlodipine, that belongs to the class of 1,4-Dihydropyridine (DHP) calcium antagonists. The parent active pharmaceutical ingredient is used in the treatment of hypertension and anginal chest pain.

Application

This pharmaceutical secondary standard can also be used as follows:

Development of a stability-indicating reverse-phase ultra-performance liquid chromatographic (RP-UPLC) method for determining related impurities of S(−)amlodipine and S(−)metoprolol succinate in their combined tablet dosage
Ultra-high pressure liquid chromatographic (UHPLC) separation and estimation of amlodipine and bisoprolol-related impurities in the combined pharmaceutical formulation of the parent APIs
Development and validation of a UHPLC method for quantifying impurities of valsartan, amlodipine besylate, and hydrochlorothiazide in their combined tablet dosage
Separation and determination of amlodipine and atorvastatin, along with their impurities using a stability-indicating RP-HPLC method in their combined solid dosage forms

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

To see an example of a Certificate of Analysis for this material enter LRAB9841 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H301,H318,H373,H410

pcodes

P260 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c