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PHR1764

Colchicine

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Colchicine, (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C22H25NO6
CAS 번호:
64-86-8
Molecular Weight:
399.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823598
EC Number:
200-598-5
Beilstein/REAXYS Number:
2228813
MDL number:
MFCD00078484
기술 서비스
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도움 문의

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C2580000, traceable to USP 1146006

API family

colchicine, thiocolchicoside

CofA

current certificate can be downloaded

packaging

pkg of 400 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

150-160 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

Gene Information

human ... TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H300,H340

Hazard Classifications

Acute Tox. 2 Oral - Muta. 1B

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Colchicine intoxication: clinical pharmacology, risk factors, features, and management.
Putterman C, et al.
Seminars in Arthritis and Rheumatism, 21(3), 143-155 (1991)
Rapid and sensitive liquid chromatography?tandem mass spectrometry method for the quantitation of colchicine in human plasma
Jiang Y. et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 850(1-2), 564-568 (2007)
Colchicine
Wyatt D K, et al.
Anal. Profiles Drug Subst., 10, 139-182 (1981)

국제 무역 품목 번호

SKUGTIN
PHR1764-400MG04061835080014