P9375
1,10-Phenanthroline monohydrate
reagent grade
동의어(들):
o-Phenanthroline monohydrate
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H8N2 · H2O
CAS 번호:
Molecular Weight:
198.22
UNSPSC Code:
12352116
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-629-2
Beilstein/REAXYS Number:
4008096
MDL number:
biological source
synthetic (organic)
Quality Level
grade
reagent grade
form
powder
mp
100-104 °C (lit.)
solubility
methanol: 200 mM (Stock solution is stable for months at –20° C.)
SMILES string
O.c1cnc2c(c1)ccc3cccnc23
InChI
1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
InChI key
PPQJCISYYXZCAE-UHFFFAOYSA-N
Gene Information
human ... FNTA(2339)
General description
Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.
Application
1,10-Phenanthroline monohydrate has been used:
- as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
- as a negative control in in situ zymography of mice heart samples
- in in vitro resveratrol chelation and reducing activities assays to chelate iron
When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
Biochem/physiol Actions
Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans
Soares MV, et al.
Free Radical Research, 52(9), 939-951 (2018)
Katy Satué et al.
Acta veterinaria Hungarica, 68(1), 79-84 (2020-05-10)
In women and females of different species of laboratory animals, oestrogens stimulate the renin-angiotensin-aldosterone system (RAAS) by increasing tissue and circulating levels of angiotensinogen and renin during the preovulatory period. Progesterone and cortisol compete with aldosterone for mineralocorticoid receptors, which
Central Role of Phenanthroline Mono-N-oxide in the Decomposition Reactions of Tris (1, 10-phenanthroline) iron (II) and-iron (III) Complexes
Beller G, et al.
Inorganic Chemistry, 49(9), 3968-3970 (2010)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| P9375-1G | 04061834402886 |
| P9375-5G | 04061834504887 |
| P9375-100G | 04061835548064 |
| P9375-25G | 04061834402916 |