78697
Methyl methanesulfonate
certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
동의어(들):
Methanesulfonic acid methyl ester
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CH3SO3CH3
CAS 번호:
Molecular Weight:
110.13
Beilstein:
1098586
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24
Grade
certified reference material
Quality Level
제품 라인
TraceCERT®
grade
TraceCERT®
유통기한
limited shelf life, expiry date on the label
제조업체/상표
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
기술
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.414 (lit.)
bp
202-203 °C (lit.)
density
1.3 g/mL at 25 °C (lit.)
응용 분야
environmental
pharmaceutical
형식
neat
저장 온도
2-8°C
SMILES string
COS(C)(=O)=O
InChI
1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3
InChI key
MBABOKRGFJTBAE-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.
Methyl methanesulfonate belongs to the group of alkyl sulfonate esters, termed as potential genotoxic impurities (GTIs).
Methyl methanesulfonate belongs to the group of alkyl sulfonate esters, termed as potential genotoxic impurities (GTIs).
애플리케이션
Methyl methanesulfonate may be used as certified reference material for the quantification of the analyte in pharmaceutical formulations using gas chromatography coupled to triple quadrupole mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
생화학적/생리학적 작용
DNA adduct; adds methyl groups to DNA at 7-guanine preferentially, but also 3-adenine and 3-guanine.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
기타 정보
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
법적 정보
TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation
표적 기관
Lungs
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
219.2 °F - closed cup
Flash Point (°C)
104 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry
Liu Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 168(3), 23-29 (2019)
Stephanie Jungmichel et al.
Molecular cell, 52(2), 272-285 (2013-09-24)
Poly(ADP-ribos)ylation (PARylation) is a reversible posttranslational modification found in higher eukaryotes. However, little is known about PARylation acceptor proteins. Here, we describe a sensitive proteomics approach based on high-accuracy quantitative mass spectrometry for the identification of PARylated proteins induced under
Nicolas Dénervaud et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(39), 15842-15847 (2013-09-11)
Observing cellular responses to perturbations is central to generating and testing hypotheses in biology. We developed a massively parallel microchemostat array capable of growing and observing 1,152 yeast-GFP strains on the single-cell level with 20 min time resolution. We measured
Mukul R Jain et al.
Cancer chemotherapy and pharmacology, 82(4), 635-647 (2018-07-27)
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in the detection and repair of DNA damage. Studies have shown that inhibition of PARP and Tankyrase (TNKS) has significant antitumor effect in several types of cancers including BRCA-negative breast cancers. Identification
Amaya Azqueta et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(2), 768-773 (2012-12-25)
A serious limitation of the conventional comet assay (single cell gel electrophoresis) is the restriction on the number of samples that can be processed in one experiment, imposed by the size of the electrophoresis platform. One approach to increasing throughput
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