43720
N,N′-Disuccinimidyl carbonate
≥95.0% (NMR), for peptide synthesis
동의어(들):
N-Succinimidyl carbonate, DSC, Di(N-succinimidyl) carbonate
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H8N2O7
CAS 번호:
Molecular Weight:
256.17
Beilstein:
1499137
EC Number:
MDL number:
UNSPSC 코드:
12352005
PubChem Substance ID:
NACRES:
NA.22
제품 이름
N,N′-Disuccinimidyl carbonate, purum, ≥95.0% (NMR)
grade
purum
Quality Level
분석
≥95.0% (NMR)
양식
powder
반응 적합성
reaction type: Carbonylations
불순물
~3% N-hydroxysuccinimide (NMR)
mp
190 °C (dec.) (lit.)
응용 분야
peptide synthesis
작용기
imide
저장 온도
−20°C
SMILES string
O=C1CCC(=O)N1OC(=O)ON2C(=O)CCC2=O
InChI
1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2
InChI key
PFYXSUNOLOJMDX-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
N,N′-Disuccinimidyl carbonate (DSC) can be used to synthesize:
It may be also used:
- Various carbamate derivatives from primary and sterically hindered secondary alcohols by alkoxycarbonylation.
- Active carbonate resins from 4-hydroxymethylpolystyrene and 4-hydroxymethyl-3-nitrobenzamido resins via hydroxy functional groups.
- Aza-glycinyl dipeptides, important intermediates for the preparation of various azapeptides.
It may be also used:
- In the two-step preparation of 5-(6-(azidomethyl)nicotinamido)pentanoic acid, a copper-chelating picolyl azide derivative.
- To activate the hydroxyl group of the hapten, γ-hydroxyphenylbutazone (HPBZ) so that HPBZ can effectively bind with human serum albumin(HSA)-immunogen to form a hapten-protein conjugate.
기타 정보
Convenient reagent for preparing N-succinimidyl esters of N-protected amino acids and other acids; activated carbonate, e.g. synthesis of ureas and carbamates; coupling of ligands to proteins (via lysines).
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - STOT RE 2 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
T. Kokubo et al.
Journal of the American Chemical Society, 109, 606-606 (1987)
N. Nimura et al.
Analytical Chemistry, 58, 2372-2372 (1986)
Arun K Ghosh et al.
Tetrahedron letters, 33(20), 2781-2784 (1992-05-12)
An efficient and mild method for alkoxycarbonylation of amines is described, utilizing commercially available N,N'-disuccinimidyl carbonate.
M Morpurgo et al.
Journal of biochemical and biophysical methods, 38(1), 17-28 (1999-03-17)
Ligands containing amino or hydroxyl groups were converted to their corresponding activated N-hydroxysuccinimidyl carbamate and carbonate by reaction with disuccinimidyl carbonate (DSC). The latter reagents can be used for the group-specific modification of primary amines as an alternative to the
A.K. Ghosh et al.
Tetrahedron Letters, 33, 2781-2781 (1992)
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