생물학적 소스
mouse
항체 형태
purified antibody
항체 생산 유형
secondary antibodies
클론
monoclonal
종 반응성
human
기술
ELISA: suitable
immunodiffusion: suitable
동형
IgG1
관련 카테고리
일반 설명
Secondary antibody specific for Human Immunoglobulin M
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.
면역원
corresponding to Human Human Serum IgM.
애플리케이션
Detect Human Serum IgM using this mouse monoclonal, Cat. No. MABX1911-10KC, validated for use in and ELISA and Lateral Flow Assay.
None
Research Category
Secondary & Control Antibodies
Secondary & Control Antibodies
생화학적/생리학적 작용
Immunoglobulin M (IgM) plays a key role in engulfing the apoptotic cells. The reduction in serum IgM levels leads to increased autoimmune response and a higher risk of infections. IgM exhibits polyreactive and autoreactive functionality. A defect in IgM production is observed in X-linked agammaglobulinemia.
Specific for Human IgM. No cross reactivity with human IgA, IgD, IgE or IgG.
물리적 형태
Format: Purified
Ion-exchange chromatography
Purified mouse monoclonal in buffer containing 50 mM NaCl, 10 mM PBS, pH 8.0, 0.1 % sodium azide (NaN₃).
제조 메모
2-8°C. For long-term storage, freeze at -20°C.
분석 메모
Tested
기타 정보
Concentration: Please refer to lot specific datasheet.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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시험 성적서(COA)
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Protective roles of natural IgM antibodies
Gronwall C, et al.
Frontiers in immunology, 3, 66-66 (2012)
Structure and function of immunoglobulins.
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
Michael R Ehrenstein et al.
Nature reviews. Immunology, 10(11), 778-786 (2010-10-16)
The existence of IgM has been known for more than a century, but its importance in immunity and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have provided unexpected insights into its role in several diverse processes
관련 콘텐츠
Products and support for mpox research, offering world-class reagents for immunoassay and molecular assay development.
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