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Merck

MAB348

Sigma-Aldrich

Anti-Beta (β)-Amyloid antibody

CHEMICON®, mouse monoclonal, 22C11

동의어(들):

APP, Anti - APP A4, Anti-amyloid precursor protein A4

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

주요 문서

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기술 서비스
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기술 서비스
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도움 문의

제품 이름

Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11, clone 22C11, Chemicon®, from mouse

생물학적 소스

mouse

Quality Level

100

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

22C11, monoclonal

종 반응성

rat, fish, human, mouse, canine, pig, monkey

제조업체/상표

Chemicon®

기술

immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

동형

IgG1

NCBI 수납 번호

NM_000484.2
NM_201413.1
NM_201414.1

UniProt 수납 번호

P05067

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... APP(351)

일반 설명

110/120/130 kDa
The β/A4 amyloid precursor protein (APP) is a transmembrane glycoprotein and exists in three isoforms. This protein is composed of a single-pass transmembrane domain, a large extracellular N-terminal domain, and a short cytoplasmic C-terminal tail. The APP gene is located on the human chromosome at 21q21.3-q22.

면역원

Epitope: a.a. 66-81 of APP {N-terminus}
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.

애플리케이션

Anti-APP A4 Antibody, a.a. 66-81 of APP , clone 22C11 has been used in immunohistochemistry and immunoblotting(1:1000).

생화학적/생리학적 작용

Anti-APP A4 Antibody reacts with pre-A4 and recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000). The Anti-APP A4 antibody is known to cross-react with APLP2 (Slunt, 1994).
The β/A4 amyloid precursor protein (APP) undergoes proteolytic cleavage and produces β/A4 peptide. The extracellular deposition of this peptide is observed in brain cortical parenchyma and cerebro-meningeal blood vessels which marks the pathological condition of Alzheimer′s disease. Mutations of the APP gene lead to the early onset of Alzheimer′s disease and hereditary cerebral hemorrhage with amyloidosis.

물리적 형태

Format: Purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Protein A purified

제조 메모

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

분석 메모

Control
Brain tissue, brain cell lysates

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.
Ho, A; Liu, X; Sudhof, TC
The Journal of Neuroscience null
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging.
Atamna, H; Killilea, DW; Killilea, AN; Ames, BN
Proceedings of the National Academy of Sciences of the USA null
Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells.
O Spadoni, A Crestini, P Piscopo, L Malvezzi-Campeggi, I Carunchio, M Pieri, C Zona, A Confaloni
Cellular and Molecular Neurobiology null
Generation and initial characterization of FDD knock in mice.
Giliberto, L; Matsuda, S; Vidal, R; D'Adamio, L
Testing null
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
Li, Yazhou, et al.
Journal of Alzheimer'S Disease, 19, 1205-1219 (2010)
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관련 콘텐츠

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