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Merck

574625

Sigma-Aldrich

Suramin sodium salt

≥98% (HPLC), crystalline solid, P2Y antagonist, Calbiochem®

동의어(들):

Suramin, Sodium Salt, P2Y Antagonist I, Purinergic Receptor P2Y Antagonist I, PTP Inhibitor VI, PTP Inhibitor VI, Purinergic Receptor P2Y Antagonist I, P2Y Antagonist I

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C51H34N6O23S6 · 6Na
CAS 번호:
129-46-4
Molecular Weight:
1429.17
MDL number:
MFCD00210217
UNSPSC 코드:
12352200
NACRES:
NA.77

주요 문서

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제품 이름

Suramin, Sodium Salt, A reversible and competitive inhibitor of protein tyrosine phosphatases.

Quality Level

100

설명

Merck USA index - 14, 9006

분석

≥98% (HPLC)

양식

crystalline solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated (hygroscopic)

색상

white

solubility

water: 5 mg/mL

배송 상태

ambient

저장 온도

2-8°C

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(c(c1)[S](=O)(=O)O)c(ccc2[S](=O)(=O)O)\N=C(/[O-])\c3cc(c(cc3)C)\N=C(/[O-])\c4cc(ccc4)\N=C(\Nc5cc(ccc5)\C(=N\c6c(ccc(c6)\C(=N\c7c8c(c(cc7)[S](=O)(=O)O)cc(cc8[S](=O)(=O)O)[S](=O)(=O)O)\[O-])C)\[O-])

InChI

1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6

InChI key

VAPNKLKDKUDFHK-UHFFFAOYSA-H

관련 카테고리

일반 설명

A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of Gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.
An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerase I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in calmodulin assays when given in combination with angiostatic steroids.

생화학적/생리학적 작용

Cell permeable: no
Primary Target
protein tyrosine phosphatases
Product does not compete with ATP.
Reversible: yes
Target IC50: 15 µM against phospholipase D

제조 메모

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130.
Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808.
Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281.
Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443.
Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717.
Denhertog, A., et al. 1992. J. Physiol.454, 591.
Nakajima, M., et al. 1991. J. Biol. Chem.266, 9661.
Wilks, J.W., et al. 1991. Int. J. Radiat. Biol.60, 73.
Huang, R.C., et al. 1990. Mol. Pharmacol.37, 304.
Kopp, R. and Pfeiffer, A. 1990. Cancer Res.50, 6490.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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