557324
Riluzole
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
동의어(들):
Riluzole, 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C8H5F3N2OS
CAS 번호:
Molecular Weight:
234.20
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
Quality Level
설명
Merck USA index - 14, 8223
분석
≥97% (HPLC)
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
white to off-white
solubility
HCl: 0.1 N
DMSO: 40 mg/mL
양이온 미량물
heavy metals: ≤20 ppm
배송 상태
ambient
저장 온도
2-8°C
SMILES string
FC(F)(F)Oc1cc2[s]c(nc2cc1)N
InChI
1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChI key
FTALBRSUTCGOEG-UHFFFAOYSA-N
일반 설명
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD).
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
Inhibits glutamate release and blocks Na+ channels
Inhibits glutamate release and blocks Na+ channels
Product does not compete with ATP.
Reversible: no
포장
Packaged under inert gas
제조 메모
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Toxicity: Toxic (F)
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 2 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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