5291
Polymyxin B Sulfate
Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.
동의어(들):
Polymyxin B Sulfate, Aerosporin
Quality Level
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
색상
white to off-white
solubility
water: 25 mg/mL
배송 상태
ambient
저장 온도
10-30°C
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
일반 설명
Polymyxin B is a polypeptide antibacterial that belongs to the polymyxin family. It exerts its effects against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter sp., and Klebsiella sp.. Polymyxin B sulfate is a mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.
애플리케이션
Polymyxin B Sulfate - CAS 1405-20-5 – Calbiochem has been used:
- to neutralize the endotoxins in bovine serum albumin
- in the in vitro treatment of hepatic stellate cells (HSCs)
- as an antibiotic in collateral sensitivity and cross-resistance analysis in Escherichia coli
생화학적/생리학적 작용
Polymyxin B possesses antiendotoxin activity. It binds to lipid A of the lipopolysaccharide (LPS) molecules and facilitates penetration by displacing Ca2+ and Mg2+ in the outer membrane of Gram-negative bacteria.
기타 정보
Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Toxicity: Harmful (C)
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Andrea Kwa et al.
Expert review of anti-infective therapy, 5(5), 811-821 (2007-10-05)
Hospital-acquired infections due to multidrug-resistant gram-negative bacteria constitute major health problems, since the medical community is continuously running out of available effective antibiotics and no new agents are in the pipeline. Polymyxins, a group of antibacterials that were discovered during
Guiqin Wu et al.
Cell chemical biology, 28(4), 524-536 (2021-01-13)
Aggregation can be selectively induced by aggregation-prone regions (APRs) contained in the target proteins. Aggregation-inducing antimicrobial peptides (Pept-ins) contain sequences homologous to APRs of target proteins and exert their bactericidal effect by causing aggregation of a large number of proteins.
Ivan Denisov et al.
Luminescence : the journal of biological and chemical luminescence, 33(6), 1054-1061 (2018-06-22)
In the present study, we demonstrate the use of a disposable luciferase-based microfluidic bioassay chip for environmental monitoring and methods for fabrication. The designed microfluidic system includes a chamber with immobilized enzymes of bioluminescent bacteria Photobacterium leiognathi and Vibrio fischeri
Anna M Bischofberger et al.
Environmental microbiology, 22(7), 2664-2679 (2020-03-13)
Bacteria in nature often encounter non-antibiotic antibacterials (NAAs), such as disinfectants and heavy metals, and they can evolve resistance via mechanisms that are also involved in antibiotic resistance. Understanding whether susceptibility to different types of antibacterials is non-randomly associated across
Yoon Mee Yang et al.
Science translational medicine, 11(496) (2019-06-14)
Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic HA and HA synthase 2 (HAS2) expression was elevated in both
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