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Merck

481480

Sigma-Aldrich

NF-κB SN50

≥97% (HPLC), lyophilized, NF-κB translocation inhibitor, Calbiochem®

동의어(들):

NF-κB SN50, Cell-Permeable Inhibitor Peptide

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C129H230N36O29S
Molecular Weight:
2781.50
UNSPSC 코드:
12352200
NACRES:
NA.77

주요 문서

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제품 이름

NF-κB SN50, Cell-Permeable Inhibitor Peptide, NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

Quality Level

100

분석

≥97% (HPLC)

양식

lyophilized

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated (hygroscopic)

solubility

water: 5 mg/mL

배송 상태

ambient

저장 온도

−20°C

관련 카테고리

일반 설명

Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

생화학적/생리학적 작용

Cell permeable: yes
Primary Target
translocation of the NF-κB active complex into the nucleus
Product does not compete with ATP.

물리적 형태

Supplied as a trifluoroacetate salt.

제조 메모

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

기타 정보

H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

법적 정보

Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Toxicity: Standard Handling (A)

시험 성적서(COA)

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문서 라이브러리 방문

Johanna R Reed et al.
PloS one, 7(9), e45877-e45877 (2012-10-03)
Tumor formation is an extensive process requiring complex interactions that involve both tumor cell-intrinsic pathways and soluble mediators within the microenvironment. Tumor cells exploit the intrinsic functions of many soluble molecules, including chemokines and their receptors, to regulate pro-tumorigenic phenotypes

관련 콘텐츠

Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

"Toll-like Receptors (TLRs) are transmembrane proteins that are expressed on various immune cells. The extracellular N-terminal region of TLRs recognizes specific pathogen components. At least 13 different members of TLR family have been identified that detect different pathogen associated molecular patterns (PAMPs), including lipopolysaccharides, flagellin, bacterial CpG DNA, and viral RNA and DNA. Recognition of PAMPs by TLRs is considered as a key process for the induction of an inflammatory response."

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