203389
Blebbistatin, Racemic
≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®
동의어(들):
InSolutionBlebbistatin, Racemic
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H16N2O2
Molecular Weight:
292.33
UNSPSC 코드:
12352200
NACRES:
NA.77
제품 이름
Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II
Quality Level
분석
≥97% (HPLC)
양식
liquid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
protect from light
배송 상태
wet ice
저장 온도
−20°C
일반 설명
A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
ATPase
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets
포장
Packaged under inert gas
물리적 형태
A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390 ) in 90% DMSO.
제조 메모
Following initial thaw, aliquot and freeze (-20°C).
기타 정보
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point (°C)
87 °C - closed cup - (Dimethylsulfoxide)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Kevin X Lau et al.
Nature communications, 11(1), 2420-2420 (2020-05-18)
Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast stem cells, which correspond to pluripotent cells at a late post-implantation stage of embryogenesis. Heterogeneity within hPSC cultures complicates this interspecies comparison.
Catarina Domingues et al.
Frontiers in cell and developmental biology, 8, 678-678 (2020-09-10)
The mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment's stiffness. Here, we explored the influence of substrate stiffness on the proteome
Jung Hoon Cho et al.
Science advances, 8(38), eabq8486-eabq8486 (2022-09-24)
Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that primary cilia in human and mouse pancreatic islets exhibit movement that is
Vivek K Gupta et al.
The Journal of cell biology, 220(8) (2021-06-17)
Epithelial cells undergo striking morphological changes during division to ensure proper segregation of genetic and cytoplasmic materials. These morphological changes occur despite dividing cells being mechanically restricted by neighboring cells, indicating the need for extracellular force generation. Beyond driving cell
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