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1.04354

L-Histidine monohydrochloride monohydrate

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP

동의어(들):

His, L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C6H9N3O2 · HCl · H2O
CAS 번호:
5934-29-2
Molecular Weight:
209.63
EC Index Number:
211-438-9
UNSPSC Code:
12352107
Beilstein/REAXYS Number:
4168261
MDL number:
MFCD00151027
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도움 문의

Quality Level

500

agency

BP, ChP, JP, Ph. Eur.

vapor pressure

<1 hPa ( 20 °C)

product line

EMPROVE® EXPERT

assay

98.5-101.0% (alkalimetric), 99.0-101.0% (perchloric acid titration)

form

solid

pH

3.5-4.5 (20 °C, 100 g/L in H2O)

mp

254 °C (dec.) (lit.)

solubility

149.55 g/L

density

1.49 g/cm3 at 20 °C

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Histidine monohydrochloride is used in biopharmaceutical manufacturing as a buffer in formulation. It is often used along with histidine to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine monohydrochloride monohydrate Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서

Use of Stabilizers and Surfactants to Prevent Protein Aggregation

This article outlines critical factors in long-term stability of proteins, and how different stabilizers protect again mechanical and thermal stress.

관련 콘텐츠

Formulation

Learn more on mAb subcutaneous or intravenous formulation, and the relevant associated products, including excipients.

국제 무역 품목 번호

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