852678
6-Mercaptopurine monohydrate
98%
동의어(들):
6-Purinethiol, 6-Thiohypoxanthine
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H4N4S · H2O
CAS 번호:
Molecular Weight:
170.19
Beilstein:
4012091
EC Number:
MDL number:
UNSPSC 코드:
12352005
PubChem Substance ID:
NACRES:
NA.22
Quality Level
분석
98%
양식
powder
mp
>300 °C (lit.)
SMILES string
O.Sc1ncnc2[nH]cnc12
InChI
1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2
InChI key
WFFQYWAAEWLHJC-UHFFFAOYSA-N
유전자 정보
human ... PPAT(5471)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
6-Mercaptopurine monohydrate is an antimetabolite and antineoplastic drug. Its cocrystallization with 4-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid or salt formation with piperazine may improve its aqueous solubility.
애플리케이션
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - Muta. 2 - Repr. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Improving the solubility of 6-Mercaptopurine via cocrystals and salts
Xu LL, et al.
Crystal Growth & Design, 12(12), 6004-6011 (2012)
Unit-cell dimensions and space group of 6-mercaptopurine monohydrate.
Hoogsteen K.
Nature, 178(4529), 379-379 (1956)
Comparative structural and spectrum analyses of 6-mercaptopurine monohydrate and 6-mercaptopurine hydrochloride
Perez-Ruiz E, et al.
Canadian Journal of Analytical Sciences and Spectroscopy, 43(3), 59-67 (1998)
Helmut Gadner et al.
Blood, 121(25), 5006-5014 (2013-04-17)
Langerhans cell histiocytosis (LCH)-III tested risk-adjusted, intensified, longer treatment of multisystem LCH (MS-LCH), for which optimal therapy has been elusive. Stratified by risk organ involvement (high [RO+] or low [RO-] risk groups), > 400 patients were randomized. RO+ patients received
Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update.
M V Relling et al.
Clinical pharmacology and therapeutics, 93(4), 324-325 (2013-02-21)
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