711489
1-Hydroxybenzotriazole hydrate
wetted with not less than 20 wt. % water, 97% dry basis
동의어(들):
HOBt Hydrate
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C6H5N3O · xH2O
CAS 번호:
Molecular Weight:
135.12 (anhydrous basis)
Beilstein:
4515
EC Number:
MDL number:
UNSPSC 코드:
12352000
PubChem Substance ID:
NACRES:
NA.22
Quality Level
분석
97% dry basis
양식
powder
품질
wetted with not less than 20 wt. % water
구성
Water content, ~20%
반응 적합성
reaction type: Addition Reactions
mp
155-158 °C (lit.)
solubility
DMF: 0.1 g/mL, clear
SMILES string
[H]O[H].On1nnc2ccccc12
InChI
1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
InChI key
PJUPKRYGDFTMTM-UHFFFAOYSA-N
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일반 설명
1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.
애플리케이션
1-Hydroxybenzotriazole hydrate is used as an additive:
- In the oligonucleotide couplings.
- In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).
- In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
Storage Class Code
4.1A - Other explosive hazardous materials
WGK
WGK 1
Flash Point (°F)
314.6 °F
Flash Point (°C)
157 °C
개인 보호 장비
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Tetrahedron Letters, 35, 3315-3315 (1994)
T Katoh et al.
International journal of peptide and protein research, 42(3), 264-269 (1993-09-01)
3-Dimethylphosphinothioyl-2(3H)-oxazolone (MPTO) was synthesized, and its ability to effect racemization-free couplings and cyclization of a peptide and its C-terminal epimer was examined. MPTO showed good reactivity in aprotic polar solvents such as N,N-dimethylformamide (DMF) and N-methylpyrrolidone. In reactivity MPTO resembles
Synlett, 733-733 (1993)
Tetrahedron Letters, 34, 6383-6383 (1993)
Injectable gel scaffold based on biopolymer microspheres via an enzymatic reaction.
Huaping Tan et al.
Advanced healthcare materials, 3(11), 1769-1775 (2014-05-17)
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