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Merck

608041

Sigma-Aldrich

L-Lysine-13C6,15N2 hydrochloride

99 atom % 13C, 99 atom % 15N, 95% (CP)

동의어(들):

SILAC Amino Acid, (S)-2,6-Diaminohexanoic acid-13C6,15N2 hydrochloride, 13C and 15N Labeled Lys, 13C and 15N Labeled lysine hydrochloride

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
H215N(13CH2)413CH(15NH2)13CO2H · HCl
CAS 번호:
1200447-00-2
Molecular Weight:
190.59
MDL number:
MFCD00144647
UNSPSC 코드:
12352209
PubChem Substance ID:
24881987
NACRES:
NA.12

주요 문서

모든 문서 보기
기술 서비스
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도움 문의

동위원소 순도

99 atom % 13C
99 atom % 15N

Quality Level

200

분석

95% (CP)

양식

solid

광학 활성

[α]25/D +20.7°, c = 2 in 5 M HCl

기술

bio NMR: suitable
protein expression: suitable

mp

263-264 °C (dec.) (lit.)

질량 이동

M+8

저장 온도

room temp

SMILES string

Cl.[15NH2][13CH2][13CH2][13CH2][13CH2][13C@H]([15NH2])[13C](O)=O

InChI

1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1;

InChI key

BVHLGVCQOALMSV-GSMNGUNQSA-N

관련 카테고리

일반 설명

Lysine is a basic ketogenic amino acid with a protonated alkyl amino group. Lysine degradation results in the formation of acetoacetate. Acetylation/deacetylation of lysine residues in histones is a mechanism to regulate chromatin organization in eukaryotes. Isotope labeled amino acids are required for the production of isotopically labeled proteins.

애플리케이션

  • L-Lysine-13C6,15N2 hydrochloride has been used in pSILAC (pulsed stable isotope labeling by amino acids in cell culture) mass spectrometry to study protein profile in cells transfected with microRNAs.
  • It has been used in SILAC isotopic labeling for the characterization of lysine racemase.
  • It has been used in SILAC labeling for phosphoproteomic measurements in neuro-2a cells treated with and without GFKP-19 (2-pyrrolidone derivative).
Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages.

포장

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
MBBD1130
MBBC8734
MBBC6579
MBBC3791
MBBC3997

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture.
Tape CJ, et al.
Molecular and Cellular Proteomics, 13, 1866-1876 (2014)
Whole cell proteome regulation by microRNAs captured in a pulsed SILAC mass spectrometry approach.
Ebner OA and Selbach M
Methods in Molecular Biology, 725, 315-331 (2011)
Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells.
Yu C, et al.
Frontiers in Physiology, 7, 635-635 (2016)
Alex A Makarov et al.
Nature communications, 10(1), 3056-3056 (2019-07-13)
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we
Roberto Ravasio et al.
Science advances, 6(15), eaax2746-eaax2746 (2020-04-15)
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of
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관련 콘텐츠

Protein Structural Analysis

단백질 구조 분석은 치료 요법에 중요한 역할을 하는 질병 바이오마커와 약물 표적을 식별하는 데 도움이 됩니다.

Protein Structural Analysis

Protein structure analysis aids in identifying disease biomarkers and drug targets crucial for therapeutic treatments.

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