SIRNA

MISSION^® siRNA Product Offerings

Name: MISSION<SUP>®</SUP> siRNA Product Offerings
Brand: SIGMA

Custom and Predesigned siRNA

Synonym(s):

Custom siRNA, High-throughput siRNA, Predesigned siRNA, siRNA, siRNA pools

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UNSPSC Code:

12352208

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Increased drought tolerance through the suppression of ESKMO1 gene and overexpression of CBF-related genes in Arabidopsis.

Fuhui Xu et al.

PloS one, 9(9), e106509-e106509 (2014-09-04)

Improved drought tolerance is always a highly desired trait for agricultural plants. Significantly increased drought tolerance in Arabidopsis thaliana (Columbia-0) has been achieved in our work through the suppression of ESKMO1 (ESK1) gene expression with small-interfering RNA (siRNA) and overexpression

Breast-cancer risk in families with mutations in PALB2.

Antonis C Antoniou et al.

The New England journal of medicine, 371(6), 497-506 (2014-08-08)

Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. We analyzed the risk of breast cancer among 362 members of

Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.

Chong He et al.

PLoS genetics, 10(12), e1004860-e1004860 (2014-12-19)

The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces

Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells.

Maria Dermit et al.

Developmental cell, 55(3), 298-313 (2020-11-11)

Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a

Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration.

Yanli Ma et al.

PloS one, 7(10), e47961-e47961 (2012-11-01)

Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 reportedly stimulates IGF

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