SAB4501401
Anti-HMGB1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
HMG-1, HMG1, High mobility group protein 1, High mobility group protein B1
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 24 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HMGB1(3146)
General description
Anti-HMGB1 Antibody detects endogenous levels of total HMGB1 protein.
High mobility group box 1 (HMGB1) is a nuclear protein that belongs to the damage-associated molecular pattern (DAMP) family. It is located on human chromosome 13q12.
Immunogen
The antiserum was produced against synthesized peptide derived from human HMGB1.
Immunogen Range: 131-180
Immunogen Range: 131-180
Biochem/physiol Actions
High mobility group box 1 (HMGB1) is involved in bone remodeling and ectopic calcification pathogenesis. It initiates neuroinflammation after epileptogenic injuries. HMGB1 also binds to chromatin and modulates gene transcription.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.
Walker LE, et al.
The Journal of Clinical Investigation, 127(6), 2118-2132 (2017)
Roles of High Mobility Group Box 1 in Cardiovascular Calcification.
Chen Q, et al.
Cellular Physiology and Biochemistry, 42(2), 427-440 (2017)
A new case of 13q12.2q13.1 microdeletion syndrome contributes to phenotype delineation.
Mandrile G,et al.
Case Reports in Genetics (2014)
Sok Park et al.
Journal of nutritional science and vitaminology, 60(3), 159-166 (2014-08-01)
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