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R7150

Ro 25-6981 hydrochloride hydrate

Name: Ro 25-6981 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

(αR)-(4-Hydroxyphenyl)-(βS)-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₉NO₂ · HCl · xH₂O

CAS Number:

919289-58-0

Molecular Weight:

375.93 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24278680

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >20 mg/mL

originator

Roche

SMILES string

O.Cl.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3

InChI

1S/C22H29NO2.ClH.H2O/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H;1H2/t17-,22+;;/m0../s1

InChI key

FEINQVNMUYISNW-HVDCVHHPSA-N

Gene Information

human ... GRIN2B(2904)

Description

Application

Ro 25-6981 hydrochloride hydrate has been used:

as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus

Biochem/physiol Actions

Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

신경과학을 위한 생체 활성 저분자

NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic-ischemic injury

Lai Q, et al.

Molecular Medicine Reports, 13(1), 206-212 (2016)

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

G Fischer et al.

The Journal of pharmacology and experimental therapeutics, 283(3), 1285-1292 (1998-02-12)

The interaction of Ro 25-6981 with N-methyl-D-aspartate (NMDA) receptors was characterized by a variety of different tests in vitro. Ro 25-6981 inhibited 3H-MK-801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0.003 microM and 149

Activation of CaMKII and GluR1 by the PSD-95-GluN2B Coupling-Dependent Phosphorylation of GluN2B in the Spinal Cord in a Rat Model of Type-2 Diabetic Neuropathic Pain.

Ya-Bing Zhu et al.

Journal of neuropathology and experimental neurology, 79(7), 800-808 (2020-05-10)

The mechanisms underlying type-2 diabetic neuropathic pain (DNP) are unclear. This study investigates the coupling of postsynaptic density-95 (PSD-95) to N-methyl-D-aspartate receptor subunit 2B (GluN2B), and the subsequent phosphorylation of GluN2B (Tyr1472-GluN2B) in the spinal cord in a rat model

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Global Trade Item Number

SKU	GTIN
R7150-25MG	04061832093215
R7150-5MG	04061836696061