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Merck

P1784

Sigma-Aldrich

Pentoxifylline

Phosphodiesterase inhibitor, solid

Synonym(s):

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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About This Item

Empirical Formula (Hill Notation):
C13H18N4O3
CAS Number:
6493-05-6
Molecular Weight:
278.31
EC Number:
229-374-5
MDL number:
MFCD00063379
UNSPSC Code:
41106305
PubChem Substance ID:
24278190
NACRES:
NA.77

Key Documents

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Product Name

Pentoxifylline, solid

form

solid

Quality Level

100

color

white

solubility

H2O: ≥43 mg/mL, colorless to almost colorless

originator

Sanofi Aventis

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

Gene Information

human ... ADORA2B(136), LITAF(9516), PDE4B(5142), TNF(7124)
rat ... Tnf(24835)

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Application

Pentoxifylline has been used:
  • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
  • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
  • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

Biochem/physiol Actions

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H362

Hazard Classifications

Acute Tox. 4 Oral - Lact.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBQ0515
BCBQ0515V
BCBM8665V
BCBM8665
BCBK5972V

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Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons
Donate-Correa J T, et al.
Journal of clinical medicine, 8(3), 287-287 (2019)
B K Reuter et al.
The American journal of physiology, 277(4 Pt 1), G847-G854 (1999-10-12)
Although the ability of nonsteriodal anti-inflammatory drugs (NSAIDs) to injure the small intestine has been well established in humans and animals, the mechanism involved in this type of injury has yet to be elucidated. The cytokine tumor necrosis factor-alpha (TNF-alpha)
PP-023-Effect of ICSI with `pentoxifylline exposed sperms? on subsequent embryo development
Mangoli V S, et al.
Reproductive Biomedicine Online, 32, S11-S11 (2016)
Pentoxifylline Enhances the Apoptotic Effect of Carboplatin in Y79 Retinoblastoma Cells
CRUZ-GALVEZ C C, et al.
In Vivo, 33(2), 401-412 (2019)
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
Naranjo T W, et al.
Pulmonary Pharmacology & Therapeutics, 24(1), 81-91 (2011)
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