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Merck

M1824

Sigma-Aldrich

MC1568

≥97% (HPLC), class II (IIa) histone deacetylas (HDAC II) inhibitor, powder

Synonym(s):

3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

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About This Item

Empirical Formula (Hill Notation):
C17H15FN2O3
CAS Number:
852475-26-4
Molecular Weight:
314.31
UNSPSC Code:
12352200
PubChem Substance ID:
329817891
NACRES:
NA.77

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Product Name

MC1568, ≥97% (HPLC)

Quality Level

100

Assay

≥97% (HPLC)

form

powder

color

orange

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

Cn1c(\C=C\C(=O)NO)ccc1\C=C\C(=O)c2cccc(F)c2

InChI

1S/C17H15FN2O3/c1-20-14(5-6-15(20)8-10-17(22)19-23)7-9-16(21)12-3-2-4-13(18)11-12/h2-11,23H,1H3,(H,19,22)/b9-7+,10-8+

InChI key

QQDIFLSJMFDTCQ-FIFLTTCUSA-N

Related Categories

Biochem/physiol Actions

MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
017M4618V
120M4602V
129K46001
129K4600

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Mahboubeh Daneshpajooh et al.
Diabetologia, 60(1), 116-125 (2016-11-01)
Pancreatic beta cell dysfunction is a prerequisite for the development of type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function and glucose homeostasis through alterations in gene regulation. Our aim was to investigate the role of HDAC7 in
Angela Nebbioso et al.
EMBO reports, 10(7), 776-782 (2009-06-06)
Histone deacetylase (HDAC) inhibitors are promising new epi-drugs, but the presence of both class I and class II enzymes in HDAC complexes precludes a detailed elucidation of the individual HDAC functions. By using the class II-specific HDAC inhibitor MC1568, we
Li Shen et al.
PloS one, 7(1), e30815-e30815 (2012-02-04)
Immunosuppressive factors such as regulatory T cells (Tregs) limit the efficacy of immunotherapies. Histone deacetylase (HDAC) inhibitors have been reported to have antitumor activity in different malignancies and immunomodulatory effects. Herein, we report the Tregs-targeting and immune-promoting effect of a
Shigeki Saito et al.
PloS one, 12(10), e0186615-e0186615 (2017-10-19)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-β1-induced EMT (epithelial-mesenchymal transition). However, the role of HDAC6
Christine Lang et al.
PLoS pathogens, 8(1), e1002483-e1002483 (2012-01-26)
Intracellular pathogens including the apicomplexan and opportunistic parasite Toxoplasma gondii profoundly modify their host cells in order to establish infection. We have shown previously that intracellular T. gondii inhibit up-regulation of regulatory and effector functions in murine macrophages (MΦ) stimulated
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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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