L8275
Lectin from Galanthus nivalis (snowdrop)
lyophilized powder
Synonym(s):
Galanthus nivalis lectin, GNL
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About This Item
Form:
lyophilized powder
form
lyophilized powder
Quality Level
potency
<20 μg per mL agglutination activity
composition
Protein, ≥90% Lowry
impurities
salt, essentially free
storage temp.
2-8°C
General description
Lectin from Galanthus nivalis (snowdrop) is a tetrameric, 12 kDa mannose binding lectin. It belongs to the family, Amaryllidacea. It is specific to α-1,3- or 1,6- linked D-mannose of carbohydrates. Snowdrop lectins are toxic to insects.
Application
Lectin from Galanthus nivalis (snowdrop) has been used:
- to coat ELISA plates
- as reverse transcriptase inhibitor
- in ELISA for detection of envelope glycoproteins of the human and simian immunodeficiency viruses
Biochem/physiol Actions
Lectin from Galanthus nivalis (snowdrop) provide resistance against pests and are used in transgenic plants. Snowdrop lectin functions as a carrier to transport fused proteins to the hemolymph as it crosses gut epithelium of target species to exhibit insecticidal effects.
GNL agglutinates rabbit erythrocytes; human erythrocytes are not agglutinated. GNL sugar specificity is directed to the nonreducing end of the terminal α-D-mannosyl residue of glycoconjugates.
Preparation Note
Purified by affinity chromatography according to Kaku.
Analysis Note
Agglutination activity is expressed in μg/ml and is determined from serial dilution in phosphate buffered saline, pH 7.2 of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of rabbit erythrocytes after 1 hr incubation at 25 °C.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
A model for the hepatitis C virus envelope glycoprotein E2
Yagnik AT, et al.
Proteins: Structure, Function, and Bioinformatics, 40, 355-366 (2000)
Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper
Rao KV, et al.
The Plant Journal, 15, 469-477 (1998)
Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
Antiviral Research, 88, 25-30 (2010)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L8275-5MG | 04061833965986 |