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Merck

G5884

Sigma-Aldrich

Guanosine 5′-triphosphate lithium salt

~95% (HPLC), G protein activator, powder

Synonym(s):

GTP lithium salt

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About This Item

Empirical Formula (Hill Notation):
C10H16N5O14P3 · xLi+
CAS Number:
85737-04-8
Molecular Weight:
523.18 (free acid basis)
MDL number:
MFCD00070012
UNSPSC Code:
41106305
PubChem Substance ID:
24895236
NACRES:
NA.77

Key Documents

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Product Name

Guanosine 5′-triphosphate lithium salt, ~95% (HPLC), powder

Assay

~95% (HPLC)

Quality Level

200

form

powder

color

white

solubility

H2O: 100 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI key

WDCLDKGIVWUKSE-GWTDSMLYSA-M

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Application

Guanosine 5′-triphosphate lithium salt has been used:
  • In ribosome activity assay.
  • In tubulin isolation and polymerization.
  • In the determination of cell viability.

Biochem/physiol Actions

GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades.
GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
Guanosine 5′-triphosphate serves as a substrate for guanosine 5′-triphosphate 3′ diphosphate diphosphatase, a hydrolyzing enzyme and guanosine triphosphate guanyltransferase.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Prepared by enzymatic phosphorylation of 5′-GMP.

Disclaimer

Stability is much better than sodium salt.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG6526
SLBW9672
SLBR5370V
SLBH2033V
SLBH8590V

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Enzyme (2005)
Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease
Santa-Maia I, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1740(3), 472-480 (2005)
Alcoholic liver disease and the mitochondrial ribosome: methods of analysis
Alcohol, 381-394 (2008)
Adelaine K W Leung et al.
Journal of molecular biology, 402(1), 154-164 (2010-07-21)
RNA is known to perform diverse roles in the cell, often as ribonucleoprotein (RNP) particles. While the crystal structure of these RNP particles could provide crucial insights into their functions, crystallographic work on RNP complexes is often hampered by difficulties
Alexander L Markowitz et al.
Bio-protocol, 12(1), e4281-e4281 (2022-02-05)
Spiral ganglion neurons (SGN) are the primary neuronal pathway for transmitting sensory information from the inner ear to the brainstem. Recent studies have revealed significant biophysical and molecular diversity indicating that auditory neurons are comprised of sub-groups whose intrinsic properties
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